{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:06:04Z","timestamp":1780999564387,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["COBRE P20\u2010GM109089"],"award-info":[{"award-number":["COBRE P20\u2010GM109089"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["IRACDA (GM088021)"],"award-info":[{"award-number":["IRACDA (GM088021)"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["LRP\u2010REACH"],"award-info":[{"award-number":["LRP\u2010REACH"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA022268"],"award-info":[{"award-number":["AA022268"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA025120\u201005S1"],"award-info":[{"award-number":["AA025120\u201005S1"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50\u2010AA022534"],"award-info":[{"award-number":["P50\u2010AA022534"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["T32\u2010CASAA (5\u2010T32AA018108\u201015)"],"award-info":[{"award-number":["T32\u2010CASAA (5\u2010T32AA018108\u201015)"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excessive alcohol use has emerged as the strongest modifiable risk factor for the development of Alzheimer's disease (AD), but the underlying neural mechanisms are only beginning to be understood. Recent preclinical work suggests that alcohol consumption may have an impact on many pathologies and phenomena crucial to the development and pathogenesis of AD. However, little attention has been focused on pure tauopathy models to closely examine tau pathogenesis and neuroinflammation within a voluntary alcohol exposure paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We exposed a mouse model of pathological tau (pTau), P301S, to a voluntary alcohol paradigm known as drinking\u2010in\u2010the\u2010dark (DID) for 21\u2009days of voluntary daily alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In P301S mice, moderate alcohol consumption contributed to gait disruptions, acceleration of pTau spread, and enhancement of damage\u2010associated microglia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This work identifies key interactions between alcohol and AD\u2010related phenotypes which set the stage for future investigation into the neurobiological mechanisms behind these interactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70123","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T08:04:31Z","timestamp":1754294671000},"page":"1936-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-1027","authenticated-orcid":false,"given":"Nicole M.","family":"Maphis","sequence":"first","affiliation":[{"name":"Department of Neurosciences, School of Medicine University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A.","family":"Furlano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medicine University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medicine University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-0683","authenticated-orcid":false,"given":"David N.","family":"Linsenbardt","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medicine University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-021-01241-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-024-00713-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104511"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-81908-7_10"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.12.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14924"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02275-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.884170"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180141"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00990-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13365"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac257"},{"key":"e_1_2_7_15_1","first-page":"419","volume-title":"Handb Clin Neurol","author":"Cohen J.A.","year":"2019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2023.100562"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28735-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105967"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06247-w"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2022.08.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106883"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-186650"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470942390.mo140229"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0232-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5607\/en22019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160603005035"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.592288"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.01.014"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415614303"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112885"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1975.36.1107"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlad031"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00269-y"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200001)15:1<24::AID-MDS1006>3.0.CO;2-X"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15049"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.778456"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv081"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14876"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0004-24.2024"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2111"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109831"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168678"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.03.003"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181c78a20"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa097"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.121"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00083"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00434-3"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052547"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00109-w"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13275"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30022-7"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01749-w"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021050"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006148"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00361-6"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01690-9"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.886634"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.5.704"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa153"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29552-6"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-129031"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"}],"container-title":["Alcohol, Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:12:10Z","timestamp":1758856330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/acer.70123"],"URL":"https:\/\/doi.org\/10.1111\/acer.70123","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}