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Certain apolipoproteins were linked to cognition, and carrying the APOE4 gene is a vulnerability factor to memory impairment in AUD patients. We explored memory deficits in alcohol\u2010dependent male mice and humans versus controls, and their relationship to Apolipoprotein AI (APOAI), apolipoprotein B (APOB), and apolipoprotein E (APOE) plasma levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6J mice underwent voluntary alcohol drinking (two\u2010bottle choice, 2BC) and chronic intermittent ethanol vapor exposure (CIE) as a model of alcohol dependence; memory was assessed by the Object Location Test (OLT) and Novel Object Recognition Test (NORT). Additionally, male AUD\u2010diagnosed patients were recruited in Spain during an alcohol dishabituation program and assessed by the Wechsler Memory Scale\u2010IV (WMS\u2010IV). Plasma APOAI, APOB, and APOE levels were checked in mice and humans by ELISA kits and Luminex immunoassay technology. APOAI immunolabeling was quantified in mouse brain in early withdrawal and following alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CIE\u20102BC mice (<jats:italic>n<\/jats:italic>\u2009=\u20098) escalated alcohol consumption compared to Air\u20102BC controls (<jats:italic>n<\/jats:italic>\u2009=\u200911) and showed deficits in spatial memory (OLT) and recognition memory (NORT) while AUD patients (<jats:italic>n<\/jats:italic>\u2009=\u200912) showed deficits in verbal and visual memory (WMS\u2010IV) versus controls (<jats:italic>n<\/jats:italic>\u2009=\u200916). Higher plasma levels of APOAI were detected in CIE\u20102BC mice and AUD patients, with no differences in APOB and APOE in animals and humans. Significant negative correlations were found between levels of APOAI, APOB, and APOE and memory function tests\/scales in the entire sample, with APOAI showing consistent results in both animals and humans. APOAI immunoreactivity was detected in the mice subfornical organ, but the signal did not differ between experimental groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both CIE\u20102BC mice and AUD patients exhibited elevated plasma levels of APOAI during early abstinence. APOAI correlated with poorer memory performance in both species, suggesting a potential role for this apolipoprotein in the context of alcohol\u2010induced cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70149","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T02:45:22Z","timestamp":1755917122000},"page":"2278-2293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL\/6J mice and men suggest a role for <scp>APOAI<\/scp>"],"prefix":"10.1111","volume":"49","author":[{"given":"Berta","family":"Escudero","sequence":"first","affiliation":[{"name":"Department of Psychobiology and Behavioral Sciences Methods, Faculty of Psychology Complutense University of Madrid  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario 12 de Octubre (imas12)  Madrid 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