{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:24:22Z","timestamp":1760487862467,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028225"],"award-info":[{"award-number":["R01AA028225"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heightened alcohol cue reactivity is associated with alcohol problems and poor alcohol use disorder outcomes. Theory suggests that this reflects a conditioned response, whereby cues repeatedly paired with chronic alcohol use become more salient. However, few studies have investigated the relative emergence of heightened alcohol cue reactivity. It is possible that this response occurs very early in individual drinking trajectories and may play a role in shaping future alcohol use behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested this hypothesis in a sample of youth (<jats:italic>n<\/jats:italic>\u2009=\u2009159; ages 16\u201319) with limited lifetime alcohol exposure (&lt;100 lifetime drinks). Participants completed a baseline cue reactivity task in which they viewed images of alcoholic beverages, high\u2010calorie foods (reward control), and neutral objects. The late positive potential (LPP), measured using electroencephalography, is a positive\u2010going event\u2010related potential measured 400\u2009ms after a visual cue. The LPP was used to index cue reactivity and scored as the average amplitude from parietal site Pz. At baseline and 12 months, participants completed a retrospective calendar of alcohol use. Participants were classified into groups based on lifetime alcohol exposure: (1)\u2009\u2264\u200910 drinks (<jats:italic>n<\/jats:italic>\u2009=\u200950), (2) \u226450 drinks (<jats:italic>n<\/jats:italic>\u2009=\u200974), (3) &gt;50 drinks (<jats:italic>n<\/jats:italic>\u2009=\u200935).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We ran a repeated measures analysis of variance to compare the effects of task condition (alcohol cues\/food cues &gt; neutral) and drink groups on LPP amplitude. Our results revealed a significant condition \u00d7 drink group interaction. Follow\u2010up analyses revealed that, for alcohol cues only, there was a significant group effect. The highest drink exposure group exhibited greater LPP relative only to the low drink exposure group. Next, we examined whether baseline LPP to alcohol cues predicted total drinks consumed 12 months later, while controlling for baseline drinking behavior. Greater LPP to alcohol cues was associated with an increase in drinks consumed at one year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Heightened alcohol cue reactivity emerges with limited alcohol use and can be predictive of future drinking behaviors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70152","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:26:06Z","timestamp":1759299966000},"page":"2163-2171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural alcohol cue reactivity as a risk factor for future drinking in youth with limited alcohol exposure"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4601-0212","authenticated-orcid":false,"given":"Kathryn C.","family":"Jenkins","sequence":"first","affiliation":[{"name":"Institute for Behavioral Medicine Research The Ohio State University  Columbus Ohio USA"},{"name":"Neuroscience Graduate Program The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiane","family":"Toleson","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Medicine Research The Ohio State University  Columbus Ohio USA"},{"name":"Department of Psychiatry and Behavioral Health The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"House","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Medicine Research The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla","family":"Kreutzer","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Medicine Research The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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