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Modeling within\u2010person clustering of impulsivity facets has the potential to aid clinical case conceptualization, and examining associations with resilience and well\u2010being outcomes can inform strength\u2010based intervention approaches. In this study, we utilized latent profile analysis (LPA) to capture the clustering of trait impulsivity facets and tested resilience as a mediational pathway linking impulsivity latent profiles to problematic alcohol use and quality of life domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 401 adults (59.9% male and 71.6% with past\u2010year AUD) who completed self\u2010reported measures of trait impulsivity (Barratt Impulsiveness Scale and UPPS\u2010P Impulsive Behavior Scale), resilience, and alcohol\u2010related outcomes were included in this study. Statistical analyses included LPA, linear regression, and path analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LPA identified three profiles that varied by overall impulsivity as well as specific levels of negative and positive urgency: Profile 1\u2014Low Impulsivity\/Urgency (36.4%), Profile 2\u2014Medium Impulsivity (45.6%), and Profile 3\u2014High Impulsivity\/Urgency (18.0%). The percentages of past\u2010year AUD were 37.7% in Profile 1, 87.4% in Profile 2, and 100% in Profile 3. Latent profiles with higher impulsivity had lower resilience, higher problematic alcohol use, and lower quality of life. Low resilience was a significant mediator of associations between Medium\/High Impulsivity profiles and all clinical outcomes, including problematic alcohol use and four quality of life domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this person\u2010centered analysis, individuals who scored high on negative urgency also had elevated scores on positive urgency and several other impulsivity facets. Within\u2010person clustering of impulsivity facets was associated with differential risk for AUD, and latent profile differences in problematic alcohol use and quality of life outcomes were mediated by low resilience. Findings highlight resilience as a potential treatment target that warrants further evaluation in clinical research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70158","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:36:23Z","timestamp":1757478983000},"page":"2365-2378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Latent profile analysis of trait impulsivity facets and associations with resilience, problematic alcohol use, and quality of life"],"prefix":"10.1111","volume":"49","author":[{"given":"Heidi H.","family":"Meyer","sequence":"first","affiliation":[{"name":"Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Human Behavior The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-2829","authenticated-orcid":false,"given":"Tommy","family":"Gunawan","sequence":"additional","affiliation":[{"name":"Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"},{"name":"Human Psychopharmacology Laboratory National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Schwandt","sequence":"additional","affiliation":[{"name":"Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-2183","authenticated-orcid":false,"given":"Vijay A.","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Human Psychopharmacology Laboratory National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Diazgranados","sequence":"additional","affiliation":[{"name":"Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-1555","authenticated-orcid":false,"given":"Jeremy W.","family":"Luk","sequence":"additional","affiliation":[{"name":"Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2012.03.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191119832660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2014.915181"},{"key":"e_1_2_10_5_1","volume-title":"AUDIT: the alcohol use disorders identification test: guidelines for use in primary health care","author":"Babor T.F.","year":"2001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh048"},{"key":"e_1_2_10_7_1","volume-title":"Impulsiveness and aggression. 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