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Alcohol influences multiple organs through interorgan and intercellular signaling cascades. The common health conditions associated with alcohol use disorder (AUD) are pancreatitis, liver cirrhosis, neuropathies, cardiomyopathies, and dementia. By virtue of its anatomical orientation and function, the lung continually encounters microbes, and this can be exacerbated by excessive alcohol consumption. Alcohol abuse is a well\u2010known risk factor for bacterial infection in the lung. Increased susceptibility to bacterial pneumonia is caused by impaired immune responses in individuals with AUD. The key cells to defend against pulmonary infections are innate immune cells, including alveolar macrophages, neutrophils, and adaptive immune cells, such as T and B cells. This review highlights recent advances illuminating the roles of innate immune responses in bacterial pneumonia and the effects of alcohol in bacterial pneumonia. Understanding the molecular mechanisms associated with innate immunity in the lung is essential for developing effective strategies to control pneumonia and alcohol\u2010mediated immunosuppression.<\/jats:p>","DOI":"10.1111\/acer.70176","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T09:08:37Z","timestamp":1759396117000},"page":"2427-2435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alcohol\u2010induced susceptibility to pulmonary bacterial infections: A narrative review"],"prefix":"10.1111","volume":"49","author":[{"given":"Tharanja","family":"Gobalakrishnan","sequence":"first","affiliation":[{"name":"Center for Lung Biology and Disease Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge, Louisiana USA"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prantho M.","family":"Dipta","sequence":"additional","affiliation":[{"name":"Center for Lung Biology and Disease Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge, Louisiana USA"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Aidoo","sequence":"additional","affiliation":[{"name":"Center for Lung Biology and Disease Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge, Louisiana USA"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Le","sequence":"additional","affiliation":[{"name":"Center for Lung Biology and Disease Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge, Louisiana USA"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-1328","authenticated-orcid":false,"given":"Samithamby","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Center for Lung Biology and Disease Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge, Louisiana USA"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine Louisiana State University and Agricultural &amp; Mechanical College  Baton Rouge Louisiana USA"},{"name":"Section of Pulmonary and Critical Care, Department of Medicine Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03974.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.09.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.6.1286"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/323661"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000095634.82310.53"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2004.08.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01825.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-120003404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00832-08"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14979"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01059.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095707"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00274.2014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00833.x"},{"key":"e_1_2_8_16_1","first-page":"213","article-title":"Alcohol\u2010attributable deaths and years of potential life lost\u201411 states, 2006\u20132010","volume":"63","author":"Gonzales K.","year":"2014","journal-title":"MMWR. 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