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Limited clinical research suggests that cannabidiol (CBD) may have therapeutic effects on anxiety disorders and addictive behavior, but efficacy has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two proof\u2010of\u2010concept trials of CBD were conducted simultaneously. In Study 1, 27 adults with moderate to severe AUD were randomized to CBD [600\u2009mg\/day for 4\u2009weeks, then 1200\u2009mg\/day for 4\u2009weeks] versus placebo. In Study 2, 30 adults with AUD plus DSM\u20105 PTSD or subthreshold post\u2010traumatic stress disorder (PTSD) were randomized to CBD 600\u2009mg\/day vs. placebo for 6\u2009weeks. The trials assessed CBD pharmacokinetics, safety and tolerability, alcohol consumption, craving, mood and anxiety symptoms, and, in Study 2, PTSD symptom severity. Efficacy analyses used mixed\u2010effects models, and the primary drinking outcome was the average number of drinks per day during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CBD was rapidly absorbed, achieving near\u2010steady\u2010state trough levels by week 1, with dose\u2010dependent increases during weeks 5\u20138 in Study 1. Mean trough and estimated peak CBD levels at week 4 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) were 31.15 (SD: 21.22) ng\/mL and 130.75 (SD: 152.57) ng\/mL, respectively. Few safety concerns emerged, but 7\/31 (22.6%) of participants assigned to CBD experienced dose\u2010limiting side effects. In both studies, participants in both treatment groups showed large reductions in drinks per day and percentage heavy drinking days during treatment (Cohen's dz.\u2009&gt;\u20090.9). Neither trial demonstrated superiority of CBD over placebo for drinking outcomes, craving, mood, anxiety, or PTSD symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the feasibility and tolerability of twice\u2010daily oral CBD up to 1200\u2009mg\/day in actively drinking individuals but do not demonstrate efficacy at the CBD levels that were achieved in this study. Further dose finding and larger, well\u2010powered trials are needed to clarify CBD's therapeutic potential in AUD and comorbid PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70212","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:58:37Z","timestamp":1764327517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of cannabidiol in alcohol use disorder patients with and without co\u2010occurring post\u2010traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof\u2010of\u2010concept trials"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-3470","authenticated-orcid":false,"given":"Michael P.","family":"Bogenschutz","sequence":"first","affiliation":[{"name":"Department of Psychiatry NYU Grossman School of Medicine  New York New York 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