{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:29:40Z","timestamp":1789709380238,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K08HL168348"],"award-info":[{"award-number":["1K08HL168348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of alcohol use disorder (AUD) and related complications, such as alcohol\u2010associated liver disease and alcohol\u2010associated cirrhosis, continues to rise in the United States. However, limited data exist on the impact of AUD in aging hospitalized populations. We aimed to evaluate the association between AUD and clinical outcomes in aging hospitalized patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 2017\u20132020 data from the Nationwide Inpatient Sample, including adults aged 18\u201380 with and without AUD based on ICD\u201010 codes (AUD:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009523,464; general medical population [GMP]:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009238,678). Primary outcomes included length of stay, discharge disposition, healthcare cost, mortality, sarcopenia, and frailty. Multivariable regression analyses were conducted within and across age strata (&lt;50, 50\u201360, 61\u201370, 71\u201380\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the GMP, patients with AUD had higher healthcare utilization and more comorbidities across all age groups. A higher proportion of females were diagnosed with AUD in each age category. The prevalence of sarcopenia and frailty increased with age, with the highest rates in AUD patients over 70. Across all age groups, AUD was independently associated with worse outcomes, including increased sarcopenia, frailty, healthcare costs, longer hospital stays, and worse discharge dispositions. Mortality risk was elevated in AUD patients under 70 (odds ratios: 1.55, 1.41, 1.21 for &lt;50, 50\u201360, 61\u201370, respectively), but not in those over 70 (OR: 0.95), suggesting survivor bias. Concurrent sarcopenia and frailty conferred greater mortality risk than either alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AUD is independently associated with worse clinical outcomes in hospitalized adults, especially older adults. These findings underscore the urgent need for age\u2010tailored alcohol intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70219","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:07:27Z","timestamp":1764659247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010related impact of outcomes in hospitalized patients with alcohol overuse"],"prefix":"10.1111","volume":"50","author":[{"given":"Dhweeja","family":"Dasarathy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-9773","authenticated-orcid":false,"given":"Amy H.","family":"Attaway","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Cleveland Clinic  Cleveland Ohio 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