{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:14:51Z","timestamp":1772997291872,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX001271"],"award-info":[{"award-number":["I01BX001271"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Corticotropin\u2010releasing factor (CRF) neurons in the medial subdivision of the central amygdala (CeM) are a distinct subpopulation of neurons in a critical brain region modulating ethanol actions. Previous studies have demonstrated enhanced release of GABA and neuropeptides in this brain region in response to acute ethanol exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed whole\u2010cell patch clamp recordings on identified CRF\u2010containing neurons (CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      ) in the CeM and measured intrinsic measures of excitability in response to acute ethanol exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      neurons are highly sensitive to actions of acute ethanol exposure, which suppresses neuronal excitability in a dose\u2010dependent manner and shortens spike duration of the CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      neurons during repetitive firing. Ethanol's inhibitory effect on neuronal excitability persists even in synaptically isolated CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      neurons, an indication of a direct action on the intrinsic membrane properties that underlie excitability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results reveal that ethanol selectively alters intrinsic firing mechanisms of CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      neurons at low dose but broadly suppresses excitability at a higher dose. These findings provide new insight into how alcohol modulates intrinsic membrane properties of these CeM\n                      <jats:sup>CRF<\/jats:sup>\n                      neurons within stress\u2010related amygdala circuits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70234","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:11:38Z","timestamp":1768810298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethanol effects on excitability of corticotropin\u2010releasing factor\u2010expressing neurons in the medial subdivision of the mouse central amygdala nucleus"],"prefix":"10.1111","volume":"50","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Behavioral Medicine and Neurosciences Division, Department of Psychiatry and Behavioral Sciences Duke University Medical Center and VISN 6 MIRECC Durham 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