{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:07:27Z","timestamp":1779088047019,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol\u2010associated liver disease (ALD) is a leading cause of liver\u2010related mortality and is increasingly recognized for its contribution to cardiovascular diseases. The renin\u2010angiotensin\u2010aldosterone system (RAAS), including angiotensin\u2010converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), has demonstrated benefits in modulating inflammatory pathways. Clinical data regarding the effects in patients with ALD remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study utilizing the TriNetX platform. Patients with ALD who were prescribed ACEI\/ARB were compared with those prescribed calcium channel blockers (CCB). Propensity score matching (1:1) was applied to balance baseline characteristics. The primary outcome was all\u2010cause mortality. Secondary outcomes included alcohol\u2010associated hepatitis (AH), major adverse cardiovascular events (MACE), major adverse liver outcomes (MALO), and sepsis. Patients were followed for 5\u2009years. Cox proportional hazards models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 7884 patients were included (3942 per group). ACEI\/ARB use was associated with a significantly lower risk of all\u2010cause mortality (HR: 0.70, 95% CI: 0.64\u20130.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with CCB use.\n                    <\/jats:p>\n                    <jats:p>\n                      Furthermore, the ACEI\/ARB cohort demonstrated significant risk reductions across all secondary outcomes, including MACE (HR: 0.69, 95% CI: 0.61\u20130.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), MALO (HR: 0.81, 95% CI: 0.73\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), AH (HR: 0.88, 95% CI: 0.80\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), and sepsis (HR: 0.61, 95% CI: 0.53\u20130.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world cohort, ACEI\/ARB use in patients with ALD was associated with reduced risks of mortality, cardiovascular events, liver events, AH, and sepsis, supporting a potential protective role of RAAS inhibition in ALD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70235","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:00:23Z","timestamp":1772964023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved survival and reduced alcohol\u2010associated hepatitis risk with renin\u2010angiotensin\u2010aldosterone system inhibitors in alcohol\u2010associated liver disease"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-165X","authenticated-orcid":false,"given":"Pojsakorn","family":"Danpanichkul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Pang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Youjiang Medical University for Nationalities  Baise Guangxi China"},{"name":"National Immunological Laboratory of Traditional Chinese Medicine  Baise Guangxi China"},{"name":"Center for Medical Laboratory Science Affiliated Hospital of Youjiang Medical University for Nationalities  Baise Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-6800","authenticated-orcid":false,"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-8014","authenticated-orcid":false,"given":"Andrew F.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"School of Medicine Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primrose","family":"Tothanarungroj","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-4315","authenticated-orcid":false,"given":"Omar","family":"Al Ta'ani","sequence":"additional","affiliation":[{"name":"Department of Medicine Allegheny Health Network  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narathorn","family":"Kulthamrongsri","sequence":"additional","affiliation":[{"name":"Department of Medicine, John A. Burns School of Medicine University of Hawai'i  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-1688","authenticated-orcid":false,"given":"Kwanjit","family":"Duangsonk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6092-2541","authenticated-orcid":false,"given":"Robert J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"},{"name":"Gastroenterology Section, Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-5061","authenticated-orcid":false,"given":"Daniel 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