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Previously, we reported that in 8\u2010week\u2010old male C57Bl\/6j mice, mPFC and BLA inputs synapse onto the same MSNs where they reciprocally inhibit each other presynaptically in a strict time\u2010dependent manner, a phenomenon called synaptic gating. However, the influence of sex and age on synaptic gating and its sensitivity to binge alcohol drinking remained unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study investigates the effects of alcohol, age, and sex on BLA\u2010mPFC and mPFC\u2010BLA synaptic gating. To investigate this biological question, we performed whole\u2010cell recordings from NAc core MSNs while independently optogenetically stimulating BLA and mPFC inputs in succession, using interstimulus intervals of 40, 65, 115, and 165\u2009ms, in 6\u2010, 8\u2010, and 12\u2010week\u2010old male and female C57Bl\/6j mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that, in alcohol\u2010na\u00efve mice, the ability of cortical inputs to inhibit the transmission of information from the BLA region changes with age. Regarding the influence of sex, mPFC gating of BLA synaptic transmission was significantly stronger in 8\u2010week\u2010old males compared with age\u2010matched females, a difference that disappeared in 12\u2010week\u2010old mice. Interestingly, the observed synaptic gating sex difference disappeared in binge alcohol drinking mice. Furthermore, binge alcohol drinking had a greater effect on BLA\u2009\u2192\u2009mPFC gating in older (12\u2010week\u2010old) than in younger (8\u2010week\u2010old) mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, our results show that age and sex influence how NAc MSNs process cortical and amygdala information through synaptic gating, a phenomenon disrupted by binge alcohol drinking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70243","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:27:16Z","timestamp":1770870436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of biological sex and age on alcohol modulation of synaptic gating in nucleus accumbens core medium spiny neurons"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-3570","authenticated-orcid":false,"given":"Timmy","family":"L\u00ea","sequence":"first","affiliation":[{"name":"Department of Neurobiology, The Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School  Worcester Massachusetts USA"},{"name":"Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Gimenez\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, The Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles E.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, The Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School  Worcester Massachusetts 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