{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:00Z","timestamp":1787013780084,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA027556"],"award-info":[{"award-number":["R01 AA027556"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical and preclinical alcohol use disorder (AUD) research demonstrates that males and females differ in motivations behind drinking, patterns of drinking behaviors, and alcohol\u2010related physiological responses and health consequences. Nonhuman primate (NHP) models of AUD have the potential to enhance our understanding of such sex differences. In NHP models, schedule\u2010induced polydipsia is a common method to initiate ethanol drinking. In males, characteristics of drinking during the final stage of induction, when monkeys consume 1.5\u2009g\/kg\/day, predict subsequent drinking patterns when monkeys have unlimited access to ethanol. The present study assessed sex differences in those predictive behaviors during induction and characterized patterns and intakes during 6\u2009months of ethanol drinking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eleven singly housed adult cynomolgus monkeys (six male, five female) were induced to consume water, then increasing doses of ethanol for 4\u2009weeks per dose (0.5, 1.0, and 1.5\u2009g\/kg) using a 300\u2010s fixed\u2010time schedule of food pellet delivery. Following induction, monkeys switched to an \u201copen\u2010access\u201d regimen wherein water and ethanol were available 22\u2009h\/day, 5\u2009days\/week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Predictive relationships between drinking characteristics during the final phase of induction and subsequent open\u2010access drinking were replicated, with no evidence of sex differences. Although weekly and total ethanol intakes were higher in males over 6\u2009months of open access, the difference did not reach statistical significance. However, there were sex differences in the distribution of ethanol intake across the day. Males drank significantly more when meals were available, whereas females spread their drinking throughout the first half of the session; these differences were exacerbated in Month 2 and remained for the duration of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results replicate previous findings of a predictive relationship between drinking variables during induction and later open\u2010access drinking and reveal sex differences in daily patterns of ethanol intake that may inform treatment approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70254","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:58:47Z","timestamp":1772963927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patterns of chronic ethanol drinking in male and female cynomolgus monkeys"],"prefix":"10.1111","volume":"50","author":[{"given":"Joshua N.","family":"Prete","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip M.","family":"Epperly","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Cronin","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Althea P.","family":"Floge","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1778-4625","authenticated-orcid":false,"given":"Paul W.","family":"Czoty","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13327"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14563"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02035.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v40.2.03"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00395-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v40.2.04"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2021.10.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15163"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbscr.2018.08.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2003.08.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00765.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-82517-1"},{"key":"e_1_2_8_14_1","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA). (2024)Alcohol use disorder (AUD) in the United States: age groups and demographic characteristics September. Available from:https:\/\/www.niaaa.nih.gov\/alcohols\u2010effects\u2010health\/alcohol\u2010topics\/alcohol\u2010facts\u2010and\u2010statistics\/alcohol\u2010use\u2010disorder\u2010aud\u2010united\u2010states\u2010age\u2010groups\u2010and\u2010demographic\u2010characteristics[Accessed 3rd January 2026]."},{"key":"e_1_2_8_15_1","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA). (2025)Alcohol use in the United States: age groups and demographic characteristics February. Available from:https:\/\/www.niaaa.nih.gov\/alcohols\u2010effects\u2010health\/alcohol\u2010topics\u2010z\/alcohol\u2010facts\u2010and\u2010statistics\/alcohol\u2010use\u2010united\u2010states\u2010age\u2010groups\u2010and\u2010demographic\u2010characteristics[Accessed 3rd January 2026]."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22281"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.05.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2024.07.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011827"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000361"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02321.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.15.4.309"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v40.2.01"}],"container-title":["Alcohol, Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.70254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:16:41Z","timestamp":1779085001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.70254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/acer.70254"],"URL":"https:\/\/doi.org\/10.1111\/acer.70254","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70254"}}