{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:03:05Z","timestamp":1792648985707,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028770"],"award-info":[{"award-number":["R01AA028770"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R00AA025384"],"award-info":[{"award-number":["R00AA025384"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic intermittent ethanol (CIE) vapor inhalation is a widely used model for studying alcohol dependence. Additionally, cues paired with ethanol can drive and invigorate seeking behavior. However, the impact of ethanol\u2010paired cues on neural activation following a history of CIE vapor exposure remains poorly understood. Here, we examined the impact of ethanol\u2010paired cues in rats with or without a history of CIE vapor exposure on neuronal activation in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and the hippocampus (HPC) using c\u2010Fos as a marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male and female Long\u2013Evans rats with a history of air or CIE vapor exposure were exposed to previously learned alcohol\u2010associated cues under extinction conditions. Rats were perfused either immediately following cue exposure or with a delay to allow the development of c\u2010Fos protein. c\u2010Fos expression levels were analyzed in the mPFC, NAc, and HPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CIE vapor exposure led to a region\u2010specific effect on cue\u2010evoked c\u2010Fos levels, with enhanced cue\u2010evoked c\u2010Fos levels observed in the prelimbic mPFC of CIE rats. Correlation analysis of c\u2010Fos expression across brain regions revealed that CIE vapor exposure also led to altered functional connectivity patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that CIE vapor exposure affects cue\u2010evoked c\u2010Fos expression in the prelimbic mPFC as well as influencing functional connectivity across regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70258","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:26:31Z","timestamp":1771557991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic intermittent ethanol vapor exposure alters local c\u2010Fos and functional connectivity patterns evoked by alcohol cues"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-5785","authenticated-orcid":false,"given":"Ankit","family":"Sood","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Hanak","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"},{"name":"Graduate Program in Neuroscience University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Carpio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runbo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Selimovic","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"},{"name":"Graduate Program in Neuroscience University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth D. C.","family":"Weir","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"},{"name":"Graduate Program in Neuroscience University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Uittenbogaard","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"},{"name":"Graduate Program in Neuroscience University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Augustin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-0418","authenticated-orcid":false,"given":"Jocelyn M.","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Discovery Team on Addiction University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.09.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000149977.95306.3A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010022\u201006192\u20108"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.187"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010002\u20101380\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858406295854"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.07.034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12686"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2007.00379.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.10.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0929s44"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2009.01051.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2009.01027.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010008\u20101324\u20103"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.09.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010004\u20101828\u20104"},{"key":"e_1_2_8_18_1","unstructured":"Hentschke H.(2025)hhentschke\/measures\u2010of\u2010effect\u2010size\u2010toolbox. GitHub.https:\/\/github.com\/hhentschke\/measures\u2010of\u2010effect\u2010size\u2010toolbox."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.01088.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.01.019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3383\u201016.2017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119844180"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.4.334"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909915117"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2024.111123"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102826.2008.01734.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.042192.116"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurosci3040050"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201018\u201007856.2002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010002\u20101267\u2010z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2010.01426.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2015.01.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.102"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00288"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.10.016"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000145781.11923.4E"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/513911"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.216"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.037"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33107"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.5.2385"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.01.018"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.130"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12804"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2015.03.008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201017543\u20104"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.11.016"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2013.08.006"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2009.00916.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.07.019"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12031"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14070"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2384\u201006.2006"}],"container-title":["Alcohol, Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70258","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.70258","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:16:26Z","timestamp":1779084986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.70258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/acer.70258"],"URL":"https:\/\/doi.org\/10.1111\/acer.70258","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70258"}}