{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:09:27Z","timestamp":1789229367452,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA014834"],"award-info":[{"award-number":["U01 AA014834"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U24 AA014811"],"award-info":[{"award-number":["U24 AA014811"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA026102"],"award-info":[{"award-number":["U01 AA026102"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA030164"],"award-info":[{"award-number":["U01 AA030164"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fetal alcohol spectrum disorders (FASD) are among the most common developmental disorders but are underdiagnosed in part because of the inaccessibility of valid screening tools. The goal of this study was to test the ability of a novel online cognitive and behavioral screening tool to accurately distinguish youth with histories of prenatal alcohol exposure (PAE) from the comparison group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children were tested at home with an online cognitive and behavioral test battery, Brief Assessment of Individual Neurobehavior\u2014online version (BRAIN\u2010online). Participants included children with (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009239) and without (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200989) histories of PAE between the ages of 5 and 17\u2009years. BRAIN\u2010online includes a parent\/caregiver\u2010completed behavioral questionnaire and seven cognitive tasks completed by the child. Performance data were analyzed using ANOVA, ROC analysis, and logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Children in the alcohol\u2010exposed group had more behavioral problems, as indicated by higher scores on the behavior rating, and performed more poorly on the cognitive tasks than children in the comparison group. Logistic regression results indicated that performance on BRAIN\u2010online distinguished the groups with a high degree of accuracy (accuracy\u2009=\u200980%, sensitivity\u2009=\u200979%, specificity\u2009=\u200983%, positive predictive value\u2009=\u200992%, negative predictive value\u2009=\u200960%). Results were not affected by attention\u2010deficit\/hyperactivity disorder (ADHD) or overall intellectual ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BRAIN\u2010online is a novel online screening tool that can distinguish individuals affected by prenatal alcohol exposure from typically developing children with a high degree of accuracy. The availability of an accessible, low\u2010cost, efficient screening tool for fetal alcohol spectrum disorders (FASD) will improve diagnostic efficiency and reduce wait times and assessment costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70261","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:30:16Z","timestamp":1772973016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>BRAIN<\/scp>\n                    \u2010online: An online cognitive and behavioral screening tool for fetal alcohol spectrum disorders"],"prefix":"10.1111","volume":"50","author":[{"given":"Sarah N.","family":"Mattson","sequence":"first","affiliation":[{"name":"Department of Psychology, Center for Behavioral Teratology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Department of Psychology, Center for Behavioral Teratology San Diego State University  San Diego California USA"},{"name":"Department of Clinical Psychology University of Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganz","family":"Chockalingam","sequence":"additional","affiliation":[{"name":"Blue Resonance, LLC  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste S.","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Psychology, Center for Behavioral Teratology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Connely","sequence":"additional","affiliation":[{"name":"Department of Psychology, Center for Behavioral Teratology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-8519","authenticated-orcid":false,"given":"Jeffrey R.","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Foroud","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine, Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2888-9051","authenticated-orcid":false,"given":"Leah","family":"Wetherill","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine, Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Academy of Pediatrics. (2024)FASD toolkit [Online]. Available from:https:\/\/www.aap.org\/en\/patient\u2010care\/fetal\u2010alcohol\u2010spectrum\u2010disorders\/diagnosis\/https:\/\/www.aap.org\/en\/patient\u2010care\/fetal\u2010alcohol\u2010spectrum\u2010disorders\/?srsltid=AfmBOoo9HdQmbSGPojuttJRDHmFVn4Pym12ATjiUnjOk5w9bdH6VBoVy[Accessed 20th January 2026]."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-019-01237-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/14.4.231"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2171"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:24:1:033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1606"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2007.08.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.06.047"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15133"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1878-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14040"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14987"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21896"},{"key":"e_1_2_8_16_1","unstructured":"McDowell Group. (2020)Summary of the economic costs of fetal alcohol syndrome\/fetal alcohol Spectrum disorder in Alaska[online]. Alaska Mental Health Trust Authority. Available from:https:\/\/akaimsreports.dhss.alaska.gov\/Reports\/report\/FASD%20Diagnostic%20Team\/FASD_Screening_Cost[Accessed 1st April 2025]."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S7256"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301615"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102172"}],"container-title":["Alcohol, Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.70261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:57:47Z","timestamp":1785520667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.70261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/acer.70261"],"URL":"https:\/\/doi.org\/10.1111\/acer.70261","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70261"}}