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HOM of both sexes exhibited greater novelty\u2010induced hyperactivity in the CPP apparatus than HET and WT mice in the first 2\u2009min. In a separate experiment, HOM mice showed enhanced locomotor activity following a 1.5\u2009g\/kg EtOH injection; however, they also displayed greater locomotor activity during habituation, suggesting basal locomotor differences. Following 1.5 and 2\u2009g\/kg injections, HOM mice exhibited EtOH\u2010induced anxiolysis in the first 5\u2009min, while the HET and WT mice did not. Lastly, HOM mice displayed a significant sedative response compared to WT animals following a 2\u2009g\/kg injection of ethanol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Ultimately, these findings validate a role for\n                      <jats:italic>Dpp6<\/jats:italic>\n                      in modulating ethanol's rewarding, anxiolytic, and sedative effects in a sex\u2010dependent manner.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70282","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T04:29:08Z","timestamp":1775363348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Dpp6<\/i>\n                    knockout mice exhibit increased ethanol conditioned place preference and acute ethanol\u2010induced anxiolytic behavior"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-636X","authenticated-orcid":false,"given":"Maribel","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Deparment of Pharmaceutical Sciences University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-7578","authenticated-orcid":false,"given":"Amanda M.","family":"Barkley\u2010Levenson","sequence":"additional","affiliation":[{"name":"Deparment of Pharmaceutical Sciences University of New Mexico Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21048"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.059"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091\u20103057(00)00360\u20109"},{"key":"e_1_2_12_5_1","unstructured":"CBHSQ Data. 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