{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:06:48Z","timestamp":1779088008519,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA026638"],"award-info":[{"award-number":["AA026638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The central nucleus of the amygdala (CeA), a key component of the extended amygdala, is critical for mediating behavioral and physiological responses to stress and alcohol exposure. While extensive research has characterized alcohol's effects on GABAergic transmission in the medial CeA (CeM), the lateral CeA (CeL) remains underexplored, despite its central role in upstream signaling within the CeA circuit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we examined the effects of acute ethanol (EtOH) on GABAergic transmission in the CeL of alcohol\u2010na\u00efve and alcohol\u2010dependent male and female Wistar rats. Alcohol dependence was induced using a chronic intermittent ethanol vapor exposure protocol. Whole\u2010cell patch\u2010clamp recordings were conducted on CeL neurons to measure spontaneous inhibitory postsynaptic currents (sIPSCs) at baseline and following acute application of 44\u2009mM EtOH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute EtOH significantly increased sIPSC frequency in CeL neurons from male rats, regardless of alcohol history, indicating enhanced presynaptic GABA release. In contrast, female rats showed no significant changes in sIPSC frequency or amplitude following acute EtOH application, whether alcohol\u2010na\u00efve or dependent. Several neuronal properties\u2014including membrane resistance, holding current, and rheobase\u2014were significantly altered in alcohol\u2010dependent females. However, overall spiking characteristics and baseline inhibitory transmission did not differ significantly between na\u00efve and dependent groups within each sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings reveal, for the first time, that acute EtOH produces sex\u2010specific effects on GABAergic transmission in the CeL, enhancing inhibitory signaling in males but not females. This pattern mirrors previous observations in the CeM and underscores the importance of including both sexes in alcohol research. Understanding the mechanisms underlying these differences may inform the development of sex\u2010specific treatments for alcohol use disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70290","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:22:14Z","timestamp":1775625734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Ethanol Significantly Enhances\n                    <scp>GABAergic<\/scp>\n                    Transmission in the Central Lateral Amygdala of Alcohol\u2010Na\u00efve and Alcohol\u2010Dependent Male Rats"],"prefix":"10.1111","volume":"50","author":[{"given":"Emaya M.","family":"Moss","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Addiction Science, and Toxicology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enkhzul","family":"Batsaikhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science, and Toxicology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Amsden","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science, and Toxicology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-1125","authenticated-orcid":false,"given":"Dean","family":"Kirson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Addiction Science, and Toxicology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.53.1.82"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao1157"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2148"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367707780378096"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09270.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01926.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09559"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.109"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.03.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.09.008"},{"key":"e_1_2_8_12_1","first-page":"185","article-title":"Neurobiology of Alcohol Dependence: Focus on Motivational Mechanisms","volume":"31","author":"Gilpin N. 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