{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:47:03Z","timestamp":1790700423939,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This narrative review evaluates glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) as potential treatments for alcohol use disorder (AUD), a major public health problem with limited treatment options. We first briefly describe the development of GLP\u20101RAs for treating type 2 diabetes and obesity and then focus on recent studies of the drugs' effects on alcohol\u2010related behaviors, both in animal models and clinical studies. We identified relevant literature by searching for studies of incretin\u2010based therapies using PubMed, Google Scholar, and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                    and reviewing the reference lists of published reviews. We limited our discussion of preclinical studies of alcohol\u2010related effects to those that provide insights into the mechanism of effects. Clinical studies comprised both observational studies, including those using electronic health records and other real\u2010world data, and randomized controlled clinical trials, including studies completed or in progress. Of the clinical studies, we include original, peer\u2010reviewed research published in English and excluded case reports, commentaries, and preprints. This yielded a total of 13 preclinical studies, 14 clinical studies, 4 published interventional trials, and 19 interventional trials in progress or completed but unpublished. We found convergent evidence from animal and human studies that GLP\u20101RAs reduce alcohol consumption and improve alcohol\u2010associated outcomes. Several randomized controlled trials (RCTs) in progress aim to test the effects of both established and novel compounds, and different drug formulations and combinations on alcohol consumption. Additional RCTs are needed to establish the efficacy of GLP\u20101RAs for treating AUD, with mechanistic studies needed to elucidate more fully their mode of action in reducing alcohol consumption.\n                  <\/jats:p>","DOI":"10.1111\/acer.70312","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:32:18Z","timestamp":1779089538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>GLP<\/scp>\n                    \u20101 Receptor Agonists for Treating Alcohol Use Disorder: A Critical Review"],"prefix":"10.1111","volume":"50","author":[{"given":"Sean","family":"Woo","sequence":"first","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Zhu","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania 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