{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:45:25Z","timestamp":1782535525176,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Chronic alcohol use alters brain networks related to reward and stress regulation, contributing to alcohol use disorder (AUD). Baclofen, a GABA\n                      <jats:sub>B<\/jats:sub>\n                      receptor agonist, reduces cue\u2010elicited neural responses and alcohol consumption, but its effects on intrinsic functional connectivity remain unclear. This study investigates the dose\u2010specific effects of baclofen on intrinsic resting\u2010state functional connectivity in treatment\u2010seeking individuals with AUD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this double\u2010blind, placebo\u2010controlled, randomized clinical trial, 29 participants with AUD were randomized to receive placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), low\u2010dose baclofen (30\u2009mg\/day,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), or high\u2010dose baclofen (75\u2009mg\/day,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) for 12\u2009weeks. Resting\u2010state fMRI data were collected at rest during week 2. A data\u2010driven parcellation approach assessed connectivity patterns across the brain and associations with percentage of heavy drinking days and percentage of days abstinent post scan were examined in an exploratory analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to placebo, high\u2010dose baclofen was associated with significant differences in intrinsic connectivity in brain regions linked with reward, stress, attentional, and salience networks. Higher connectivity was observed between the somatomotor network and regions involved in stress regulation (e.g., hypothalamus) and reward processing, while lower connectivity was observed within salience and attentional networks. These changes were not observed in the low\u2010dose or placebo groups. Although nonsignificant, associations between MES and clinical outcomes demonstrated moderate, directionally consistent effects for abstinence\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010dose baclofen may modulate intrinsic brain connectivity in key networks implicated in AUD, including systems involved in attention and stress regulation. Although statistically significant relationships between functional connectivity and clinical outcomes were not identified, trends suggest that connectivity differences between high\u2010dose baclofen and placebo may be relevant to treatment response. These neurobiological findings provide additional support for baclofen as a dose\u2010dependent pharmacotherapy for AUD and highlight the need for larger samples to clarify the relationship between intrinsic connectivity and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT01711125,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01711125<\/jats:ext-link>\n                      letter of completion\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70332","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:49:59Z","timestamp":1780660199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baclofen Modulates Neural Intrinsic Functional Connectivity in Treatment\u2010Seeking Individuals With Alcohol Use Disorder"],"prefix":"10.1111","volume":"50","author":[{"given":"Warren B.","family":"Logge","sequence":"first","affiliation":[{"name":"Edith Collins Centre for Translational Research in Alcohol, Drugs and Toxicology Royal Prince Alfred Hospital, Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Specialty of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales 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