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PF\u20105190457 is a GHSR inverse agonist and the first GHSR inhibitor to advance to human trials. Our lab conducted two placebo\u2010controlled human laboratory studies to investigate the effects of PF\u20105190457 (100\u2009mg\/day) on alcohol craving in an alcohol cue\u2010exposure paradigm. Study 1 found reduced craving under drug versus placebo, whereas Study 2 did not replicate these findings, likely due to a floor effect and reflective of the differences in AUD populations (Study 1: active drinkers; Study 2: abstinent, inpatient).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present work is a secondary analysis combining these datasets and using subgroups based on alcohol cue\u2010reactivity (\u201ccue\u2010reactors,\u201d CR\n                      <jats:sup>+<\/jats:sup>\n                      vs. \u201cnonreactors,\u201d CR\n                      <jats:sup>\u2212<\/jats:sup>\n                      ) or the Penn Alcohol Craving Scale (\u201cPACS high cravers\u201d vs. \u201cPACS low cravers\u201d) as an additional independent variable to reanalyze the effects of PF\u20105190457 on alcohol craving (Alcohol Urge Questionnaire [AUQ]) following a \u201crelaxation\u201d trial (no cues) and an \u201calcohol cue\u201d trial (mock bar\u2010lab and preferred alcohol\u2010containing drink). Cue\u2010reactivity was calculated as the difference in AUQ between trials (AUQ\n                      <jats:sub>Alc<\/jats:sub>\n                      \u2010AUQ\n                      <jats:sub>Rel<\/jats:sub>\n                      ) and analyzed by subgroups as a separate outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PF\u20105190457 reduced AUQ scores relative to placebo following the alcohol cue trial in the CR\n                      <jats:sup>+<\/jats:sup>\n                      subgroup, but not the CR\n                      <jats:sup>\u2212<\/jats:sup>\n                      subgroup. PF\u20105190457 also reduced AUQ compared to placebo following both the relaxation and alcohol cue trial in the PACS high craver subgroup, but not in the PACS low craver subgroup. Cue\u2010reactivity was not affected by PF\u20105190457 in any subgroup analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results are preliminary and based on secondary analyses, but suggest that PF\u20105190457 could help reduce general, self\u2010reported craving for alcohol in high\u2010craving individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70366","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:15:38Z","timestamp":1782807338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Secondary, Subgroup Analysis of Alcohol Cue\u2010Exposure Craving in Response to Pharmacological Inhibition of the Growth Hormone Secretagogue Receptor With\n                    <scp>PF<\/scp>\n                    \u20105190457"],"prefix":"10.1111","volume":"50","author":[{"given":"Ryan E.","family":"Tyler","sequence":"first","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, NIDA Intramural Research Program and NIAAA Division of Intramural Clinical and Biological Research NIH  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie Espinal","family":"Abreu","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, NIDA Intramural Research Program and NIAAA Division of Intramural Clinical and Biological Research NIH  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4212","authenticated-orcid":false,"given":"Mehdi","family":"Farokhnia","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, NIDA Intramural Research Program and NIAAA Division of Intramural Clinical and Biological Research NIH  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-8754","authenticated-orcid":false,"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, NIDA Intramural Research Program and NIAAA Division of Intramural Clinical and Biological Research NIH  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.087015"},{"key":"e_1_2_10_3_1","volume-title":"Structured Clinical Interview for DSM\u20105 Disorders\u2014Clinician Version (SCID\u20105\u2010CV)","author":"American Psychiatric Association","year":"2016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830030047008"},{"key":"e_1_2_10_5_1","volume-title":"AUDIT\u2010The Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Heath Care","author":"Babor T. 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