{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:13Z","timestamp":1793032873627,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA031708"],"award-info":[{"award-number":["R21 AA031708"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA028680"],"award-info":[{"award-number":["R01 AA028680"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol use disorder (AUD) remains a significant global health challenge, necessitating the exploration of novel pharmacotherapeutics. Our recent study observed that intranasal (IN) administration of arginine vasopressin (AVP) decreases voluntary consumption of sweetened ethanol (EtOH) in mice, a promising development, given that IN AVP does not affect the blood pressure or stress responses associated with systemic AVP administration. To characterize AVP's potential to regulate alcohol drinking, here we investigated the effects of IN AVP on voluntary intake of unsweetened ethanol (EtOH) in single\u2010 and group\u2010housed mice, the involvement of AVP and Oxytocin (Oxt) receptors, and the potential neural substrates of these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experiment 1 examined the effects of treatments on two\u2010bottle choice (2 BC) drinking in single\u2010housed C57BL\/6J mice. Experiment 2 examined the effects of treatments on 2 BC drinking in group\u2010housed C57BL\/6J mice. Experiment 3 examined the effects of IN AVP on c\u2010Fos expression in brain regions containing AVP and Oxt receptors in group\u2010housed C57BL\/6J mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IN AVP (1.0\u2009mg\/kg) decreased EtOH intake in single\u2010housed mice, an effect attenuated by pretreatment with Avpr1a, Avpr1b, or Oxtr antagonists. A higher dose of AVP (3.0\u2009mg\/kg) also inhibited EtOH intake in single\u2010housed mice, and this effect was blocked by the Avpr1a antagonist SR\u201049059. In group\u2010housed mice, IN AVP (3.0\u2009mg\/kg) decreased EtOH intake, an effect blocked by the Avpr1a antagonist or Avpr1b antagonist. IN AVP (3.0\u2009mg\/kg) induced c\u2010Fos expression in the central nucleus of amygdala (CeA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IN AVP decreases voluntary EtOH intake in both single\u2010 and group\u2010housed mice. The suppressive effects of IN AVP involve Avpr1a in single\u2010housed mice. In group\u2010housed mice, this effect involves Avpr1a and Avpr1b and engages the CeA. These findings suggest IN AVP may be a potential therapeutic target for AUD, warranting its further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70374","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:37:28Z","timestamp":1784518648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single\u2010 and Group\u2010Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors"],"prefix":"10.1111","volume":"50","author":[{"given":"Michelle A.","family":"Nipper","sequence":"first","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Zweig","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-3775","authenticated-orcid":false,"given":"Andrey E.","family":"Ryabinin","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107454"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104385"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115714"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05741-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108561"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01268-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722002483"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00291.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000232"},{"key":"e_1_2_9_11_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin K. B.","year":"2008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.695409"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092012099"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"Hanson L. R. J. M.Fine A. L.Svitak andK. A.Faltesek.2013.\u201cIntranasal Administration of CNS Therapeutics to Awake Mice.\u201dJournal of Visualized Experiments.","DOI":"10.3791\/4440"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.67"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00092"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13028"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00314-B"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2024.1380031"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1179\/147683008X301577"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146761"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01046-x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13359"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.27"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15942-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0772-0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.70021"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/357336a0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.09.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.01.003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.03.007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00308-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110745"},{"key":"e_1_2_9_34_1","unstructured":"NIAAA.2025.\u201cAlcohol Facts and Statistics.\u201d[Online].https:\/\/www.niaaa.nih.gov\/alcohols\u2010effects\u2010health\/alcohol\u2010topics\/alcohol\u2010facts\u2010and\u2010statistics."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06962-0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01490-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.125"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12903"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-04-0337"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01125.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.02.006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.06.009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.07.002"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.842609"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.12.022"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2024.08.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2023_444"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1594-10.2010"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104324"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14217"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.025"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721004104"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.016"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419656"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-024-06551-7"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006421"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12893"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2022.105175"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0799-2"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0325-6"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06812-z"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01532.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13544"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105412"}],"container-title":["Alcohol, Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.70374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.70374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:17:27Z","timestamp":1793031447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.70374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/acer.70374"],"URL":"https:\/\/doi.org\/10.1111\/acer.70374","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70374"}}