{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:18:24Z","timestamp":1788178704244,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX002303"],"award-info":[{"award-number":["RX002303"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 CX001356"],"award-info":[{"award-number":["IK2 CX001356"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014373","name":"Wu Tsai Neurosciences Institute, Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The neurocognitive dysfunction observed in Alcohol Use Disorder (AUD) is related to a complex interplay between genetic, neurobiological, and environmental factors. The \u03bc\u2010opioid receptor (MOR), encoded by the\n                      <jats:italic>OPRM1<\/jats:italic>\n                      gene, modulates reward processing, stress responsivity, and excitatory\u2013inhibitory activity within prefrontal\u2013limbic and hippocampal circuits implicated in neurocognition. The common A118G (Asn40Asp, rs1799971) polymorphism alters MOR expression and signaling, but its contribution to domain\u2010specific cognitive functioning in AUD, particularly among Veterans, has received limited investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Veterans (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009127) in residential treatment for AUD completed a neurocognitive battery assessing the following domains of functioning: auditory\u2010verbal and visuospatial learning and memory, executive function, and working memory. Participants were genotyped for\n                      <jats:italic>OPRM1<\/jats:italic>\n                      A118G, and A homozygotes and G\u2010allele carriers (AG\/GG) were compared on the above measures, using bootstrapped generalized linear models, adjusted for age, education, biological sex, race, pre\u2010study alcohol consumption, and brain\u2010derived neurotrophic factor (\n                      <jats:italic>BDNF<\/jats:italic>\n                      ) (rs6265) and catechol\u2010O\u2010methyltransferase (\n                      <jats:italic>COMT<\/jats:italic>\n                      ) (rs4680) genotypes, which have been previously shown to be associated with neurocognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      G\u2010allele carriers demonstrated significantly worse performance than A homozygotes on measures of auditory\u2010verbal learning and memory, cognitive flexibility\/set shifting, auditory working memory, and on a composite average of all measures.\n                      <jats:italic>BDNF<\/jats:italic>\n                      or\n                      <jats:italic>COMT<\/jats:italic>\n                      genotypes were not associated with any measure, and there were no significant interactions among\n                      <jats:italic>OPRM1<\/jats:italic>\n                      ,\n                      <jats:italic>BDNF<\/jats:italic>\n                      , and\n                      <jats:italic>COMT<\/jats:italic>\n                      genotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Findings suggest that altered MOR signaling in G\u2010allele carriers may be associated with differences in prefrontal network efficiency, potentially justifying future studies investigating the relationship between\n                      <jats:italic>OPRM1<\/jats:italic>\n                      and glutamatergic plasticity. The results highlight a potential genetically influenced contributor to the neurocognitive heterogeneity in AUD and underscore the possible value of integrating MOR\u2010related biological markers into neurocognitive assessment of individuals with AUD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70385","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:48:00Z","timestamp":1785732480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <i>OPRM1<\/i>\n                    A118G G Allele Is Associated With Poorer Auditory\u2010Verbal Learning and Memory, Executive Functions, and Working Memory in Veterans Undergoing Residential Treatment for Alcohol Use Disorder"],"prefix":"10.1111","volume":"50","author":[{"given":"Roberto","family":"Andrade","sequence":"first","affiliation":[{"name":"Sierra\u2010Pacific Mental Illness Research and Education Clinical Centers Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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