{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:00:38Z","timestamp":1790694038324,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA014834"],"award-info":[{"award-number":["U01 AA014834"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F31AA031895"],"award-info":[{"award-number":["F31AA031895"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U24AA014811"],"award-info":[{"award-number":["U24AA014811"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA026102"],"award-info":[{"award-number":["U01AA026102"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA030164"],"award-info":[{"award-number":["U01AA030164"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["T32AA013525"],"award-info":[{"award-number":["T32AA013525"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnostic process for fetal alcohol spectrum disorders (FASD) requires investments in both time and cost. The Brief Assessment of Individual Neurobehavior, online version (BRAIN\u2010online), is a screening tool designed to identify cognitive and behavioral symptoms associated with FASD. BRAIN\u2010online is effective in distinguishing individuals with histories of prenatal alcohol exposure (PAE) and FASD; however, criterion validity of this screening tool has not been established. The goal of this study was to evaluate performance on BRAIN\u2010online against gold\u2010standard methods of measuring cognitive functioning (i.e., in\u2010person neuropsychological assessment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants included 157 children (5\u201317\u2009y) with (AE;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009101) and without (CON;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) PAE as part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) Phases 4 and 5. Individuals completed BRAIN\u2010online and underwent a standardized in\u2010person neuropsychological assessment battery; caregivers completed the BRAIN\u2010online Behavior Questionnaire (BBQ) and a standardized behavioral questionnaire. BRAIN\u2010online measures were matched to in\u2010person measures, and scores were assessed for correlation. In addition, equivalence testing was performed on BRAIN\u2010online measures and their parallel in\u2010person measures. To assess clinical utility, neurobehavioral impairment as defined by clinical guidelines for diagnosing FASD was assessed using BRAIN\u2010online and in\u2010person neuropsychological assessment and compared to FASD diagnoses using sensitivity, specificity, and accuracy analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven of the eight BRAIN\u2010online scores were correlated with scores of their corresponding in\u2010person measures, and seven of eight BRAIN\u2010online subtests showed measurement equivalence with parallel in\u2010person neuropsychological assessment measures. BRAIN\u2010online and in\u2010person neuropsychological assessment had similar accuracy rates of classifying FASD, with BRAIN\u2010online having slightly higher sensitivity and slightly lower specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BRAIN\u2010online subtests are correlated with and show measurement equivalence with gold\u2010standard measures of cognitive functioning. Therefore, BRAIN\u2010online may have clinical utility in identifying individuals who have symptoms associated with FASD and can benefit from comprehensive neuropsychological evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70414","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:09:47Z","timestamp":1789186187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validity of an Online Cognitive Screening Tool for\n                    <scp>FASD<\/scp>\n                    : Testing the Equivalence of\n                    <scp>BRAIN<\/scp>\n                    \u2010online to Neuropsychological Assessment Measures"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-7914","authenticated-orcid":false,"given":"C. 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R.","family":"Kelm","sequence":"additional","affiliation":[{"name":"Center for Behavioral Teratology and Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3148-6054","authenticated-orcid":false,"given":"D.","family":"Connely","sequence":"additional","affiliation":[{"name":"Center for Behavioral Teratology and Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chockalingham","sequence":"additional","affiliation":[{"name":"Blue Resonance, LLC  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-8519","authenticated-orcid":false,"given":"J.","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8499-9605","authenticated-orcid":false,"given":"S. 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