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A major need for advancing our understanding of this relationship is accessible preclinical behavioral batteries that can be used to disassociate the effects of adolescent alcohol on select PFC circuits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study uses a retrograde viral approach to identify PFC projection neurons to the mediodorsal thalamus (MdT), followed by intermittent access to alcohol (IA EtOH) during adolescence on the 2\u2010bottle choice procedure to model voluntary alcohol consumption. Following adolescent IA EtOH or water control, we evaluated performance on a battery of tasks to assess anxiety and cognition. Last, morphological analyses of spine density were performed for PFC\u2010MdT neurons of adolescent IA EtOH and water control mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results indicate that compared to water\u2010only controls, male and female mice that voluntarily consumed alcohol during adolescence demonstrate performance deficits in the object\u2010in\u2010place recognition task, without affecting the novel object recognition task, Y\u2010maze alternation, anxiety\u2010like behavior, or locomotion, an outcome consistent with PFC and MdT dysfunction. Morphological assessment of PFC neurons from male and female mice following behavioral tasks found a reduction in spine density in basal and apical, but not oblique dendrites of PFC\u2010MdT neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, these results implicate PFC\u2010to\u2010MdT circuit integrity as a potential substrate for the effects of adolescent alcohol on spatial recognition memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70415","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:46:22Z","timestamp":1789703182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Impairment of Spatial Recognition Memory and Reduced Frontal Corticothalamic Spine Density Following Adolescent Alcohol Consumption"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5117-9807","authenticated-orcid":false,"given":"Grace","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology LSU Health\u2010New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8057-7553","authenticated-orcid":false,"given":"Hannah","family":"Jarrell","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology LSU Health\u2010New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology LSU Health\u2010New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2650-2496","authenticated-orcid":false,"given":"Hernan","family":"Mejia\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology LSU Health\u2010New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-424X","authenticated-orcid":false,"given":"Michael C.","family":"Salling","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology LSU Health\u2010New Orleans  New Orleans Louisiana USA"},{"name":"Alcohol &amp; Drug Abuse Center of Excellence LSU Health\u2010New Orleans  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.03.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.07.031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4472"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113703"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4568"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.024"},{"key":"e_1_2_8_10_1","first-page":"1321","article-title":"Chronic Stress Impairs Rat Spatial Memory on the Y Maze, and This Effect Is Blocked by Tianeptine Treatment","volume":"110","author":"Conrad C. 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