{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:23:59Z","timestamp":1786443839114,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T00:00:00Z","timestamp":1351814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Whether responses to antidepressants differ in bipolar and unipolar depression remains unresolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed patient characteristics and outcomes of antidepressant treatment of 1036 depressed patients with bipolar\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder, or unipolar major depression, using bivariate and multivariate methods and survival analysis, testing the hypothesis that responses would be superior in unipolar depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antidepressants were given to 84.8% (878\/1036) of depressed patients: 58.9% of 93 bipolar\u2010I, 80.1% of 117 bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and 91.3% of 668 unipolar disorder cases. The 158 not given antidepressants had more manias\/year, spent more months in mania and depression, and were far more likely to receive mood stabilizers or antipsychotics long term. Improvement of <jats:styled-content style=\"fixed-case\">HDRS<\/jats:styled-content><jats:sub>21<\/jats:sub> depression ratings ranked: bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (69.6%)\u00a0&gt;\u00a0bipolar\u2010I (62.9%)\u00a0&gt;\u00a0unipolar (57.9%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), independent of initial illness severity. Responder rates (\u226550% improved without switching) ranked: bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (77.0%)\u00a0&gt;\u00a0bipolar\u2010I (71.6%)\u00a0&gt;\u00a0unipolar (61.7%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Remission rates (final <jats:styled-content style=\"fixed-case\">HDRS<\/jats:styled-content>\u00a0&lt;\u00a07) ranked: 54.0%, 50.6%, and 40.8% respectively (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02); 67.5% remitted within 12\u00a0weeks of treatment. Survival\u2010computed median time to remission (15.0\u00a0weeks, overall) was shortest for bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> patients (10.7\u00a0weeks). The 3\u2010month risk of switching into mania\u2013hypomania ranked: bipolar\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (15.8%)\u00a0&gt;\u00a0bipolar\u2010I (8.60%)\u00a0&gt;\u00a0unipolar (0.56%). Multivariate modeling found bipolar diagnosis, shorter latency to remission, more recent trial year, and fewer weeks depressed before treatment to be associated with greater percent improvement of <jats:styled-content style=\"fixed-case\">HDRS<\/jats:styled-content> ratings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Selective use of antidepressants with or without mood stabilizers in non\u2010agitated, depressed bipolar disorder patients for short periods was effective with moderate risk of potentially dangerous, manic mood elevation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12023","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T03:06:39Z","timestamp":1351911999000},"page":"355-364","source":"Crossref","is-referenced-by-count":55,"title":["Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders"],"prefix":"10.1111","volume":"127","author":[{"given":"L.","family":"Tondo","sequence":"first","affiliation":[{"name":"International Consortium for Bipolar Disorder Research, Mailman Research Center McLean Division of Massachusetts General Hospital Boston MA USA"},{"name":"Centro Lucio Bini Mood Disorders Center Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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