{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:30:07Z","timestamp":1789630207522,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,9]],"date-time":"2012-12-09T00:00:00Z","timestamp":1355011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Objective<\/jats:title>To compare the efficacy of mindfulness\u2010based cognitive therapy (MBCT<\/jats:styled-content>) plus treatment as usual (TAU<\/jats:styled-content>) to TAU<\/jats:styled-content> alone for patients with bipolar disorder over a 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec>Method<\/jats:title>Participants with a DSM<\/jats:styled-content>\u2010IV<\/jats:styled-content> diagnosis of bipolar disorder were randomly allocated to either MBCT<\/jats:styled-content> plus TAU<\/jats:styled-content> or TAU<\/jats:styled-content> alone. Primary outcome measures were time to recurrence of a DSM<\/jats:styled-content>\u2010IV<\/jats:styled-content> major depressive, hypomanic or manic episode; the M<\/jats:styled-content>ontgomery\u2010\u00c5<\/jats:styled-content>sberg D<\/jats:styled-content>epression R<\/jats:styled-content>ating S<\/jats:styled-content>cale (MADRS<\/jats:styled-content>); and Y<\/jats:styled-content>oung M<\/jats:styled-content>ania R<\/jats:styled-content>ating S<\/jats:styled-content>cale (YMRS<\/jats:styled-content>). Secondary outcome measures were number of recurrences, the D<\/jats:styled-content>epression A<\/jats:styled-content>nxiety S<\/jats:styled-content>tress S<\/jats:styled-content>cales (DASS<\/jats:styled-content>), and the S<\/jats:styled-content>tate T<\/jats:styled-content>rait A<\/jats:styled-content>nxiety I<\/jats:styled-content>nventory (STAI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Ninety\u2010five participants with bipolar disorder were recruited to the study (MBCT<\/jats:styled-content>\u00a0=\u00a048; TAU<\/jats:styled-content>\u00a0=\u00a047). Intention\u2010to\u2010treat (ITT<\/jats:styled-content>) analysis found no significant differences between the groups on either time to first recurrence of a mood episode or total number of recurrences over the 12\u2010month period. Furthermore, there were no significant between\u2010group differences on the MADRS<\/jats:styled-content> or YMRS<\/jats:styled-content> scales. A significant between\u2010group difference was found in STAI<\/jats:styled-content> \u2013 state anxiety scores. There was a significant treatment by time interaction for the DAS<\/jats:styled-content> \u2013 achievement subscale.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>While MBCT<\/jats:styled-content> did not lead to significant reductions in time to depressive or hypo\/manic relapse, total number of episodes, or mood symptom severity at 12\u2010month follow\u2010up, there was some evidence for an effect on anxiety symptoms. This finding suggests a potential role of MBCT<\/jats:styled-content> in reducing anxiety comorbid with bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12033","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T21:01:20Z","timestamp":1355259680000},"page":"333-343","source":"Crossref","is-referenced-by-count":104,"title":["A randomized controlled trial of mindfulness\u2010based cognitive therapy for bipolar disorder"],"prefix":"10.1111","volume":"127","author":[{"given":"T.","family":"Perich","sequence":"first","affiliation":[{"name":"School of Psychiatry University of New South Wales Sydney Australia"},{"name":"Black Dog Institute Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Manicavasagar","sequence":"additional","affiliation":[{"name":"School of Psychiatry University of New South Wales Sydney Australia"},{"name":"Black Dog Institute Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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