{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:12:54Z","timestamp":1774116774097,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Progression from cognitive impairment (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) to dementia is predicted by several factors, but their relative importance and interaction are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We investigated numerous such factors in the AgeCoDe study, a longitudinal study of general practice patients aged 75+. We used recursive partitioning analysis (<jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>) to identify hierarchical patterns of baseline covariates that predicted dementia\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 784 non\u2010demented patients with CI, 157 (20.0%) developed dementia over a follow\u2010up interval of 4.5\u00a0years. RPA showed that more severe cognitive compromise, revealed by a Mini\u2010Mental State Examination (MMSE) score\u00a0&lt;\u00a027.47, was the strongest predictor of imminent dementia. Dementia\u2010free survival time was shortest (mean 2.4\u00a0years) in such low\u2010scoring patients who also had impaired instrumental activities of daily living (<jats:styled-content style=\"fixed-case\">iADL<\/jats:styled-content>) <jats:italic>and<\/jats:italic> subjective memory impairment with related worry (SMI\u2010w). Patients with identical characteristics but without SMI\u2010w had an estimated mean dementia\u2010free survival time of 3.8\u00a0years, which was still shorter than in patients who had subthreshold MMSE scores but intact <jats:styled-content style=\"fixed-case\">iADL<\/jats:styled-content> (4.2\u20135.2\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hierarchical patterns of readily available covariates can predict dementia\u2010free survival in older general practice patients with CI. Although less widely appreciated than other variables, <jats:styled-content style=\"fixed-case\">iADL<\/jats:styled-content> impairment appears to be an especially noteworthy predictor of progression to dementia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12129","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T08:54:11Z","timestamp":1364028851000},"page":"63-72","source":"Crossref","is-referenced-by-count":28,"title":["A hierarchy of predictors for dementia\u2010free survival in old\u2010age: results of the AgeCoDe study"],"prefix":"10.1111","volume":"129","author":[{"given":"T.","family":"Luck","sequence":"first","affiliation":[{"name":"Institute of Social Medicine Occupational Health and Public Health University of Leipzig Leipzig Germany"},{"name":"Douglas Mental Health University Institute McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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