{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T14:10:26Z","timestamp":1715523026255},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To further explore the implication of the serotonin (5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) system in the improvement of rat short\u2010term object recognition after administration of the type 2 phosphodiesterase inhibitor (<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>\u2010I)<jats:styled-content style=\"fixed-case\">BAY<\/jats:styled-content>60\u20107550 and the type 5<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>\u2010I vardenafil, the effect of<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>2 and<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>5 inhibition upon central amino acid levels, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, and related parameters were measured after applying acute tryptophan depletion (<jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Wistar rats were orally administered saline or a protein\u2013carbohydrate mixture with or without tryptophan (<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>).<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\u2010depleted animals additionally received an oral vehicle injection or the<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>inhibitors<jats:styled-content style=\"fixed-case\">BAY<\/jats:styled-content>60\u20137550 or vardenafil at a dose known to improve object memory performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although<jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>significantly decreased<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>levels in the hippocampus 2\u00a0h after administration, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>levels appeared only moderately affected, without any changes observed in the amount of 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content>or 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>turnover rate. Moreover, no effects of<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>inhibition upon 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>or related parameters were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>neurotransmitter activity might be excluded as a potential underlying mechanism of the previously reported ability of<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>inhibitors to improve short\u2010term object memory in rats. It is suggested that a decrease in cerebral blood flow potentially underlies<jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>\u2010induced object memory deficits, most likely due to decrease in<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>synthesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12166","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T10:31:41Z","timestamp":1371465101000},"page":"107-113","source":"Crossref","is-referenced-by-count":5,"title":["No effect of acute tryptophan depletion on phosphodiesterase inhibition\u2013related improvements of short\u2010term object memory in male<scp>W<\/scp>istar rats"],"prefix":"10.1111","volume":"128","author":[{"given":"E. 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