{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:25:48Z","timestamp":1782307548659,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess the cost\u2010effectiveness of three empirically supported treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>), pharmacotherapy using a selective serotonin reuptake inhibitor (<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>), or the combination of both (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Cost\u2010effectiveness was examined based on the data from a multicenter randomized controlled trial. The <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>amilton <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nxiety <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ating <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale was selected as a primary health outcome measure. Data on costs from a societal perspective (i.e., direct medical, direct non\u2010medical, and indirect non\u2010medical costs) were collected in the study sample (<jats:italic>N<\/jats:italic>\u00a0=\u00a0150) throughout a 24\u2010month period in which patients received active treatment during the first twelve months and were seen twice for follow\u2010up in the next twelve months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total costs were largely influenced by costs of the interventions and productivity losses. The mean total societal costs were lower for <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> as compared to <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>. Costs of medication use were substantial for both <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>. When examining the balance between costs and health outcomes, both <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> led to more positive outcomes than <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cognitive behavioral therapy is associated with the lowest societal costs. Cognitive behavioral therapy and <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> are more cost\u2010effective treatments for panic disorder with or without agoraphobia as compared to <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12169","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T11:56:41Z","timestamp":1372852601000},"page":"286-295","source":"Crossref","is-referenced-by-count":16,"title":["Cost\u2010effectiveness of <scp>CBT<\/scp>,<scp> SSRI<\/scp>, and <scp>CBT<\/scp>+<scp>SSRI<\/scp> in the treatment for panic disorder"],"prefix":"10.1111","volume":"129","author":[{"given":"F. J.","family":"van Apeldoorn","sequence":"first","affiliation":[{"name":"University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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A.","family":"den Boer","sequence":"additional","affiliation":[{"name":"University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2009.07.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.07.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478\u20107547\u20107\u20108."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0710"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0085818"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.19.2529"},{"key":"e_1_2_9_8_1","first-page":"75","article-title":"Combining cognitive\u2010behavioral therapy and pharmacotherapy for the treatment of panic disorder","volume":"20","author":"Smits JAJ","year":"2006","journal-title":"J Cogn Ther"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00359-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200206000-00010"},{"issue":"4","key":"e_1_2_9_11_1","first-page":"28","article-title":"Cognitive\u2010behavioral therapy and the treatment of panic disorder: efficacy and strategies","volume":"66","author":"Otto MW","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04681blu"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90011-2"},{"key":"e_1_2_9_14_1","first-page":"1","volume-title":"Clinical handbook of psychological disorders","author":"Craske MG","year":"1993"},{"key":"e_1_2_9_15_1","first-page":"7","volume-title":"Richtlijn farmacotherapie angststoornissen","author":"Balkom AJ","year":"1998"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01157.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6296(94)00044-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.948"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220070-00002"},{"key":"e_1_2_9_20_1","volume-title":"Methods for the economic evaluation of health care programmes","author":"Drummond MF","year":"1997"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9001000308"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.903"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.766"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.23.100901.140534"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462303000412"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.54.3.327"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.012"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.12169","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.12169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:03:21Z","timestamp":1695477801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.12169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,3]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/acps.12169"],"URL":"https:\/\/doi.org\/10.1111\/acps.12169","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,3]]}}}