{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:11:58Z","timestamp":1789985518844,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Predominant polarity (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) is an important variable in maintenance treatment of bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>). This study aimed at determining the role of polarity index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), a metric indicating antimanic versus antidepressive prophylactic potential of drugs, in clinical decision\u2010making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two hundred and fifty\u2010seven of 604 (43%) of patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> fulfilled criteria for manic (<jats:styled-content style=\"fixed-case\">MPP<\/jats:styled-content>) or depressive <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>, representing the ratio of number needed to treat (<jats:styled-content style=\"fixed-case\">NNT<\/jats:styled-content>) for depression prevention to <jats:styled-content style=\"fixed-case\">NNT<\/jats:styled-content> for mania prevention, was calculated for patients' current treatment. <jats:styled-content style=\"fixed-case\">MPP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content> groups were compared regarding sociodemographic, clinical and therapeutic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010three patients (55.6%) fulfilled criteria for <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content> and 114 (44.4%) for <jats:styled-content style=\"fixed-case\">MPP<\/jats:styled-content>. Total <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>, Antipsychotics' <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>, and mood stabilizers <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> were higher, indicating a stronger antimanic action, in <jats:styled-content style=\"fixed-case\">MPP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MPP<\/jats:styled-content> presented higher prevalence of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>, male gender, younger age, age at onset and at first hospitalization, more hospitalizations, primary substance misuse, and psychotic symptoms. <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content> correlated with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, depressive onset, primary life events, melancholia, and suicide attempts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results confirm the usefulness of the <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>. In this large sample, clinical differences among these groups justify differential treatment approach. The <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> appears to be a useful operationalization of what clinicians do for maintenance therapy in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12179","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T09:30:47Z","timestamp":1374226247000},"page":"366-374","source":"Crossref","is-referenced-by-count":86,"title":["Clinical implications of predominant polarity and the polarity index in bipolar disorder: a naturalistic study"],"prefix":"10.1111","volume":"129","author":[{"given":"D.","family":"Popovic","sequence":"first","affiliation":[{"name":"Bipolar Disorders Program Department of Psychiatry Clinical Institute of Neuroscience Hospital Cl\u00ednic University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Torrent","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Program Department of Psychiatry Clinical Institute of Neuroscience Hospital Cl\u00ednic University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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