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This article reviews the data regarding the pathophysiological foundations of \u2018psychosomatic\u2019 symptoms and the implications that this has for conceptualization of what may more appropriately be termed physio\u2010somatic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This narrative review used papers published in PubMed, Scopus, and Google Scholar electronic databases using the keywords: depression and chronic fatigue, depression and somatization, somatization and chronic fatigue syndrome, each combined with inflammation, inflammatory, tryptophan, and cell\u2010mediated immune (<jats:styled-content style=\"fixed-case\">CMI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The physio\u2010somatic symptoms of depression, <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>, and somatization are associated with specific biomarkers of inflammation and <jats:styled-content style=\"fixed-case\">CMI<\/jats:styled-content> activation, which are correlated with, and causally linked to, changes in the tryptophan catabolite (<jats:styled-content style=\"fixed-case\">TRYCAT<\/jats:styled-content>) pathway. Oxidative and nitrosative stress induces damage that increases neoepitopes and autoimmunity that contribute to the immuno\u2010inflammatory processes. These pathways are all known to cause physio\u2010somatic symptoms, including fatigue, malaise, autonomic symptoms, hyperalgesia, intestinal hypermotility, peripheral neuropathy, etc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Biological underpinnings, such as immune\u2010inflammatory pathways, may explain, at least in part, the occurrence of physio\u2010somatic symptoms in depression, somatization, or myalgic encephalomyelitis\/chronic fatigue syndrome and thus the clinical overlap among these disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12182","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T05:57:01Z","timestamp":1376719021000},"page":"83-97","source":"Crossref","is-referenced-by-count":101,"title":["Biological phenotypes underpin the physio\u2010somatic symptoms of somatization, depression, and chronic fatigue syndrome"],"prefix":"10.1111","volume":"129","author":[{"given":"G.","family":"Anderson","sequence":"first","affiliation":[{"name":"CRC Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Berk","sequence":"additional","affiliation":[{"name":"School of Medicine Deakin University Melbourne Vic. 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