{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:19:06Z","timestamp":1789607946411,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) is consistently associated with acute mood episodes in bipolar disorder, but there is a lack of longitudinal data to support this hypothesis. In this 16\u2010week open\u2010label clinical trial, we tested the predictive role of <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> Val66Met polymorphism on serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels and the relationship of serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> and clinical response in people with bipolar disorder during an acute illness episode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010four people with bipolar disorder who were medication\u2010free at baseline and in an acute mood episode were recruited. They were matched with 64 healthy controls. Clinical evaluation, serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> Val66Met polymorphism were determined at baseline, and change in serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> was assessed in patients at weeks 2, 4, 8 and 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences between patients and controls in serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> or in frequencies of the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> Val66Met polymorphism genotype at baseline. The multivariable model showed that Met carriers had a significantly different change in <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels compared with Val homozygotes. Not achieving a complete remission was also associated with lower prospectively assessed <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides the first longitudinal evidence that both the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> Val66Met polymorphism and remission status predict change in circulating <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12192","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T06:06:43Z","timestamp":1376978803000},"page":"393-400","source":"Crossref","is-referenced-by-count":25,"title":["Val66Met polymorphism and serum brain\u2010derived neurotrophic factor in bipolar disorder: an open\u2010label trial"],"prefix":"10.1111","volume":"129","author":[{"given":"I.","family":"Grande","sequence":"first","affiliation":[{"name":"Bipolar Disorders Unit IDIBAPS CIBERSAM Clinical Institute of Neurosciences Hospital Cl\u00ednic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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R.","family":"Fries","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Postgraduate Program in Biological Sciences: Biochemistry Universidade Federal do Rio Grande do Sul Porto Alegre Brazil Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Cereser","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2. B. 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