{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:56:05Z","timestamp":1791251765265,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Psychopharmacology remains the foundation of treatment for bipolar disorder, but medication adherence in this population is low (range 20\u201364%). We examined medication adherence in a multisite, comparative effectiveness study of lithium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The Lithium Moderate Dose Use Study (Li<jats:styled-content style=\"fixed-case\">TMUS<\/jats:styled-content>) was a 6\u2010month, six\u2010site, randomized effectiveness trial of adjunctive moderate dose lithium therapy compared with optimized treatment in adult out\u2010patients with bipolar <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder (<jats:italic>N<\/jats:italic>\u00a0=\u00a0283). Medication adherence was measured at each study visit with the Tablet Routine Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 4.50% of participants reported missing at least 30% of their medications in the past week at baseline and non\u2010adherence remained low throughout the trial (&lt;7%). Poor medication adherence was associated with more manic symptoms and side\u2010effects as well as lower lithium serum levels at mid\u2010 and post\u2010treatment, but not with poor quality of life, overall severity of illness, or depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Participants in Li<jats:styled-content style=\"fixed-case\">TMUS<\/jats:styled-content> were highly adherent with taking their medications. The lack of association with possible predictors of adherence, such as depression and quality of life, could be explained by the limited variance or other factors as well as by not using an objective measure of adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12202","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:40:46Z","timestamp":1381545646000},"page":"359-365","source":"Crossref","is-referenced-by-count":33,"title":["Medication adherence in a comparative effectiveness trial for bipolar disorder"],"prefix":"10.1111","volume":"129","author":[{"given":"L. G.","family":"Sylvia","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Reilly\u2010Harrington","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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