{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:06:29Z","timestamp":1762430789760},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the differential response to amisulpride in patients with paranoid versus disorganized schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We reanalyzed the original data from five different randomized drug trials comparing Brief Psychiatric Rating Scale (<jats:styled-content style=\"fixed-case\">BPRS<\/jats:styled-content>) scores in a database containing 427 paranoid and 296 disorganized patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the disorganized and the paranoid group showed a substantial improvement of the <jats:styled-content style=\"fixed-case\">BPRS<\/jats:styled-content> total score within the first 4\u00a0weeks. In the paranoid group, mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">BPRS<\/jats:styled-content> reduction was 16.9 (\u00b114.6) (<jats:italic>t<\/jats:italic>\u00a0=\u00a024.06, df\u00a0=\u00a0426, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and in the disorganized group 17.0 (\u00b115.9) (<jats:italic>t<\/jats:italic>\u00a0=\u00a018.49, df\u00a0=\u00a0295, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). An analysis of covariance (<jats:sc>ancova<\/jats:sc>) controlling for <jats:styled-content style=\"fixed-case\">BPRS<\/jats:styled-content> at baseline and the influence of different trial protocols showed significant differences between diagnostic groups (<jats:italic>F<\/jats:italic>\u00a0=\u00a013.47, df\u00a0=\u00a01, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Cohen's D 0.31 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.16\u20130.46). Paranoid patients improved by 4.8 <jats:styled-content style=\"fixed-case\">BPRS<\/jats:styled-content> points more than disorganized patients (adjusted means 18.90 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a017.33\u201320.37) for the paranoid and 14.1 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a012.04 \u2013 16.11) for the disorganized group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that amisulpride is effective in disorganized as well as in paranoid schizophrenia, but that symptom reduction in the disorganized subtype is less pronounced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12231","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T05:16:37Z","timestamp":1386047797000},"page":"40-45","source":"Crossref","is-referenced-by-count":6,"title":["Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?"],"prefix":"10.1111","volume":"130","author":[{"given":"C.","family":"Corves","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Technische Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"Psychiatrische Klinik und Poliklinik Klinikum der LMU Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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