{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:17:38Z","timestamp":1791357458304,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Clinical guidelines recommend slow clozapine dose titration in order to decrease the risk of seizures and hypotension. The recommendation may delay adequate control of severe psychotic symptoms. We evaluated the safety and effectiveness of rapid clozapine titration in patients who had been previously exposed to the drug and in patients who received clozapine for the first time after failing to respond to other antipsychotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Analysis of hospital course of a consecutive cohort of schizophrenia patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a0111) who received 25\u2013100\u00a0mg of clozapine as needed every 6\u00a0h the first treatment day, followed by upward adjustments of 25\u2013100\u00a0mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptom control was obtained with an average dose of 353\u00a0\u00b1\u00a0174\u00a0mg\/day after 4.1\u00a0\u00b1\u00a03.1\u00a0days in the 73 patients previously treated with clozapine. For the 38 patients initially started on other antipsychotics, the average clozapine dose required for symptom control (409\u00a0\u00b1\u00a0188\u00a0mg\/day) was reached after 7.1\u00a0\u00b1\u00a04.8\u00a0days. None of the patients had seizures, severe hypotension or other major adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this naturalistic cohort study rapid clozapine titration appeared safe and effective for the treatment of schizophrenia. The results justify controlled clinical trials of this treatment method.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12241","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:17:16Z","timestamp":1387520236000},"page":"25-29","source":"Crossref","is-referenced-by-count":39,"title":["Effectiveness and safety of rapid clozapine titration in schizophrenia"],"prefix":"10.1111","volume":"130","author":[{"given":"P.","family":"Ifteni","sequence":"first","affiliation":[{"name":"Faculty of Medicine Transilvania University Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Aalborg Psychiatric Hospital Aarhus University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Burtea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Transilvania University Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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