{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:27:01Z","timestamp":1791268021425,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq Universal","award":["473424\/2009-6"],"award-info":[{"award-number":["473424\/2009-6"]}]},{"DOI":"10.13039\/501100007762","name":"CNPq-INCTTM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007762","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNPq\/PP","award":["306431\/2009-2"],"award-info":[{"award-number":["306431\/2009-2"]}]},{"name":"Fundo de Incentivo \u00c3\u00a0 Pesquisa \u00e2\u20ac\u201c Hospital de Cl\u00c3\u00adnicas de Porto Alegre (FIPE-HCPA)"},{"name":"Young Investigator Award from NARSAD","award":["472455\/2008-7"],"award-info":[{"award-number":["472455\/2008-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"\n Objective<\/jats:title>\n \n The impact of childhood trauma (\n CT<\/jats:styled-content>\n ) on brain\u2010derived neurotrophic factor (\n BDNF<\/jats:styled-content>\n ) and cytokines levels remains unclear. We investigated the association between\n CT<\/jats:styled-content>\n and changes in\n BDNF<\/jats:styled-content>\n and cytokines plasma levels in children.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n We recruited 36 children with trauma (\n CT<\/jats:styled-content>\n +) and 26 children without trauma (\n CT<\/jats:styled-content>\n \u2010). The presence of\n CT<\/jats:styled-content>\n was based on a clinical interview and by Criteria A of\n DSM<\/jats:styled-content>\n \u2010\n IV<\/jats:styled-content>\n criteria for\n PTSD<\/jats:styled-content>\n . Blood samples were drawn from all children to assess\n BDNF<\/jats:styled-content>\n and cytokines.\n ancova<\/jats:sc>\n was performed with psychiatric symptoms and\n BMI<\/jats:styled-content>\n as covariates to evaluate group differences in plasma levels.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CT<\/jats:styled-content>\n + showed increased levels of\n BDNF<\/jats:styled-content>\n and\n TNF<\/jats:styled-content>\n \u2010\u03b1 after excluding children with history of inflammatory disease (\n P\u00a0<\/jats:italic>\n <\u00a00.05) when compared with those\n CT<\/jats:styled-content>\n \u2010.\n IL<\/jats:styled-content>\n \u201012p70,\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u20108,\n IL<\/jats:styled-content>\n \u201010, and\n IL<\/jats:styled-content>\n \u20101\u03b2 levels were not statistically different between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n CT<\/jats:styled-content>\n + showed increased\n BDNF<\/jats:styled-content>\n and proinflammatory cytokines levels. The increase in\n BDNF<\/jats:styled-content>\n levels may be an attempt to neutralize the negative effects of\n CT<\/jats:styled-content>\n , while an increase in\n TNF<\/jats:styled-content>\n \u2010a levels be associated with a proinflammatory state after\n CT<\/jats:styled-content>\n . How these changes associated with trauma relate to other biological changes and illness trajectory later in life remain to be further studied.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.12358","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T07:19:38Z","timestamp":1416208778000},"page":"360-368","source":"Crossref","is-referenced-by-count":45,"title":["Brain\u2010derived neurotrophic factor and inflammatory markers in school\u2010aged children with early trauma"],"prefix":"10.1111","volume":"131","author":[{"given":"J.","family":"B\u00fccker","sequence":"first","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Fries","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Bioqu\u00edmica Universidade Federal do Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kapczinski","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Post","sequence":"additional","affiliation":[{"name":"Clinical Professor of Psychiatry George Washington University Washington DC"},{"name":"Bipolar Collaborative Network Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N.","family":"Yatham","sequence":"additional","affiliation":[{"name":"Bipolar Collaborative Network Bethesda MD USA"},{"name":"Department of Psychiatry University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vianna","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Bogo Chies","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Gama","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. V.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Bipolar Disorder Program and Laboratory of Molecular Psychiatry National Institute for Translational Medicine INCT\u2010TM Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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