{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:03:31Z","timestamp":1790503411058,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institute of Health Reserch","award":["97914"],"award-info":[{"award-number":["97914"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Post\u2010traumatic stress disorder (PTSD) is considered a multidimensional disorder, with distinct symptom clusters including re\u2010experiencing, avoidance\/numbing, hyperarousal, and most recently depersonalization\/derealization. However, the extent of differing intrinsic network connectivity underlying these symptoms has not been fully investigated. We therefore investigated the degree of association between resting connectivity of the salience (SN), default mode (DMN), and central executive (CEN) networks and PTSD symptom severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Using resting\u2010state functional MRI data from PTSD participants (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      21), we conducted multivariate analyses to test whether connectivity of extracted independent components varied as a function of re\u2010experiencing, avoidance\/numbing, hyperarousal, and depersonalization\/derealization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hyperarousal symptoms were associated with reduced connectivity of posterior insula\/superior temporal gyrus within SN [peak Montr\u00e9al Neurological Institute (MNI): \u221244, \u22128, 0,\n                      <jats:italic>t\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      \u22124.2512,\n                      <jats:italic>k\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      40]. Depersonalization\/derealization severity was associated with decreased connectivity of perigenual anterior cingulate\/ventromedial prefrontal cortex within ventral anterior DMN (peak MNI: 8, 40, \u22124;\n                      <jats:italic>t\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      \u22123.8501;\n                      <jats:italic>k\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      15) and altered synchrony between two DMN components and between DMN and CEN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results are consistent with prior research showing intrinsic network disruptions in PTSD and imply heterogeneous connectivity patterns underlying PTSD symptom dimensions. These findings suggest possible biomarkers for PTSD and its dissociative subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.12387","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T03:06:35Z","timestamp":1420772795000},"page":"29-38","source":"Crossref","is-referenced-by-count":142,"title":["Distinct intrinsic network connectivity patterns of post\u2010traumatic stress disorder symptom clusters"],"prefix":"10.1111","volume":"132","author":[{"given":"M.","family":"Tursich","sequence":"first","affiliation":[{"name":"Department of Psychiatry The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ros","sequence":"additional","affiliation":[{"name":"Department of Fundamental Neurosciences The University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Frewen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Western Ontario London ON Canada"},{"name":"Department of Psychology The University of Western Ontario London ON Canada"},{"name":"Department of Neuroscience The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Kluetsch","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. D.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering The University of New Mexico Albuquerque NM USA"},{"name":"The Mind Research Network Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Lanius","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Western Ontario London ON Canada"},{"name":"Department of Neuroscience The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01755.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.10.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01281.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.057"},{"key":"e_1_2_10_7_1","first-page":"75","article-title":"Exploring the psychosis functional connectome: aberrant intrinsic networks in schizophrenia and bipolar disorder","volume":"2","author":"Calhoun VD","year":"2011","journal-title":"Front Psychiatry"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.21029"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318273bf33"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.06.003"},{"key":"e_1_2_10_13_1","first-page":"187","article-title":"Alterations in default network connectivity in posttraumatic stress disorder related to early\u2010life trauma","volume":"34","author":"Bluhm RL","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.09.029"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.07.016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171300250X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.122"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405900602"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22291"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096834"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22155"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-013-0157-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22615"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01391.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046833"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-289.v1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.09.013"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-1-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.08.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.027"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.08.006"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.028"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.031"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.07.014"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.197"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4939-12.2013"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020981"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.04.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21889"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21944"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21946"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.08.022"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.011"},{"key":"e_1_2_10_46_1","volume-title":"Multiscale Dissociation Inventory","author":"Briere J","year":"2002"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.108.s417.3.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12143"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02030.x"},{"key":"e_1_2_10_50_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition (SCID\u2010I\/P)","author":"First MB","year":"2002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12229"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.8.1132"},{"key":"e_1_2_10_53_1","volume-title":"Manual for the State\u2010Trait Anxiety Inventory","author":"Spielberger CD","year":"1983"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20024"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/15299732.2012.678470"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.046"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2733"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.027"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21170"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp052"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348867"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1103-13.2013"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.049"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01773.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0021264"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2012.2211076"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1024"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090047"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.12387","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.12387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:11:29Z","timestamp":1696475489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.12387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/acps.12387"],"URL":"https:\/\/doi.org\/10.1111\/acps.12387","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]}}}