{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:04:02Z","timestamp":1789160642793,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RN158849"],"award-info":[{"award-number":["RN158849"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["274056"],"award-info":[{"award-number":["274056"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the effects of light therapy on serotonin transporter binding (5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      ), an index of 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content>\n                      levels, in the anterior cingulate and prefrontal cortices (\n                      <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>\n                      ) of healthy individuals during the fall and winter. Twenty\u2010five per cent of healthy individuals experience seasonal mood changes that affect functioning. 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      has been found to be higher across multiple brain regions in the fall and winter relative to spring and summer, and elevated 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      may lead to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would reduce 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      in the\n                      <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>\n                      , which sample brain regions involved in mood regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In a single\u2010blind, placebo\u2010controlled, counterbalanced, crossover design, [\n                      <jats:sup>11<\/jats:sup>\n                      C]\n                      <jats:styled-content style=\"fixed-case\">DASB<\/jats:styled-content>\n                      positron emission tomography was used measure 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      following light therapy and placebo conditions during fall and winter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In winter, light therapy significantly decreased 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      by 12% in the\n                      <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>\n                      relative to placebo (\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>1,9<\/jats:sub>\n                      \u00a0=\u00a018.04,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.002). In the fall, no significant change in 5\u2010\n                      <jats:styled-content style=\"fixed-case\">\n                        HTT BP\n                        <jats:sub>ND<\/jats:sub>\n                      <\/jats:styled-content>\n                      was found in any region across conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results identify, for the first time, a central biomarker associated with the intervention of light therapy in humans which may be applied to further develop this treatment for prevention of seasonal depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.12424","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T00:43:23Z","timestamp":1429317803000},"page":"379-388","source":"Crossref","is-referenced-by-count":36,"title":["Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex"],"prefix":"10.1111","volume":"132","author":[{"given":"S. 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