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We tested for a birth\u2010cohort effect on <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content> using admixture analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A clinical sample of 3896 <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2010I cases was analysed using two approaches: (i) in a subsample with untruncated <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content>\u00a0\u00d7\u00a0birth year distribution (<jats:italic>n<\/jats:italic>\u00a0=\u00a01865), we compared the best\u2010fitting model for the observed <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content> in patients born \u22641960 and &gt;1960, (ii) to control for potential confounders, two separate subsamples born \u22641960 and &gt;1960 were matched for age at interview (<jats:italic>n<\/jats:italic>\u00a0=\u00a0250), and a further admixture analysis was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two approaches indicated that the proportion of cases in the early <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content> category was significantly greater in cases born &gt;1960; manic onsets were also more frequent in the early onset <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2010I cases born &gt;1960.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decrease in <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2010I in recent birth\u2010cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean <jats:styled-content style=\"fixed-case\">AAO<\/jats:styled-content> in each putative subgroup. 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