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We examine whether course of anxiety disorders (<jats:styled-content style=\"fixed-case\">ANX<\/jats:styled-content>), attention deficit hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>), disruptive behavior disorders (<jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>), and substance use disorders (<jats:styled-content style=\"fixed-case\">SUD<\/jats:styled-content>) influence likelihood of recovery and recurrence of depression and mania in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> youth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Weekly ratings of psychiatric disorder intensity were obtained from 413 participants of the Course and Outcome of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> Youth project, followed for an average of 7.75 years. Multiple\u2010event Cox proportional hazards regression analyses examined worsening of comorbid disorders as predictors of mood episode recovery and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased severity in <jats:styled-content style=\"fixed-case\">ANX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SUD<\/jats:styled-content> predicted longer time to recovery and less time to next depressive episode, and less time to next manic episode. Multivariate models with <jats:styled-content style=\"fixed-case\">ANX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SUD<\/jats:styled-content> found that significant effects of <jats:styled-content style=\"fixed-case\">ANX<\/jats:styled-content> remained, but <jats:styled-content style=\"fixed-case\">SUD<\/jats:styled-content> only predicted longer time to depression recovery. Increased severity of <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content> predicted shorter time to recurrence for depressive and manic episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are significant time\u2010varying relationships between the course of comorbid disorders and episodicity of depression and mania in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> youth. Worsening of comorbid conditions may present as a precursor to mood episode recurrence or warn of mood episode protraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12514","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T11:30:02Z","timestamp":1445081402000},"page":"324-334","source":"Crossref","is-referenced-by-count":30,"title":["The influence of comorbid disorders on the episodicity of bipolar disorder in youth"],"prefix":"10.1111","volume":"133","author":[{"given":"S.","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Human Behavior Alpert Medical School of Brown University Providence RI USA"},{"name":"Butler Hospital Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Stout","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Alpert Medical School of Brown University Providence RI USA"},{"name":"Pacific Institute for Research and Evaluation Pawtucket RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hower","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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