{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:17:09Z","timestamp":1791303429991,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Objective<\/jats:title>To provide meta\u2010analytical evidence of bone mineral density (BMD<\/jats:styled-content>), fractures, and osteoporosis rates in eating disorders (ED<\/jats:styled-content>) vs. healthy controls (HC<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Method<\/jats:title>Three independent authors searched major electronic databases from inception till August 2015 for cross\u2010sectional studies reporting BMD<\/jats:styled-content> in people with ED<\/jats:styled-content> (anorexia nervosa, (AN<\/jats:styled-content>); bulimia nervosa, (BN<\/jats:styled-content>); eating disorders not otherwise specified, (EDNOS<\/jats:styled-content>)) vs. HC<\/jats:styled-content>s. Standardized mean differences (SMD<\/jats:styled-content>s) \u00b195% and confidence intervals (CI<\/jats:styled-content>s) were calculated for BMD<\/jats:styled-content>, and odds ratios (OR<\/jats:styled-content>s) for osteopenia, osteoporosis, and fractures.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 57 studies were eligible, including 21 607 participants (ED<\/jats:styled-content> = 6485, HC<\/jats:styled-content>s = 15 122). Compared to HC<\/jats:styled-content>, AN<\/jats:styled-content> subjects had significantly lower BMD<\/jats:styled-content> values at lumbar spine (SMD<\/jats:styled-content> = \u22121.51, 95% CI<\/jats:styled-content> = \u22121.75, \u22121.27, studies = 42), total hip (SMD<\/jats:styled-content> = \u22121.56, 95%CI<\/jats:styled-content> = \u22121.84, \u22121.28, studies = 23), intertrochanteric region (SMD<\/jats:styled-content> = \u22121.80, 95%CI<\/jats:styled-content> = \u22122.46, \u22121.14, studies = 7), trochanteric region (SMD<\/jats:styled-content> = \u22121.05, 95%CI<\/jats:styled-content> = \u22121.44, \u22120.66, studies = 7), and femoral neck (SMD<\/jats:styled-content> = \u22120.98, 95%CI<\/jats:styled-content> = \u22121.12, \u22120.77, studies = 20). Reduced BMD<\/jats:styled-content> was moderated by ED<\/jats:styled-content> illness duration and amenorrhea (P<\/jats:italic> < 0.05). AN<\/jats:styled-content> was associated with an increased likelihood of osteoporosis (OR<\/jats:styled-content> = 12.59, 95%CI<\/jats:styled-content> = 3.30\u201347.9, P<\/jats:italic> < 0.001, studies = 4) and fractures (OR<\/jats:styled-content> = 1.84, 95% CI<\/jats:styled-content> = 1.17\u20132.89, I<\/jats:italic>2<\/jats:sup> = 56, studies = 6). No difference in BMD<\/jats:styled-content> was found between BN<\/jats:styled-content> and EDNOS<\/jats:styled-content> vs. HC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>People with AN<\/jats:styled-content> have reduced BMD<\/jats:styled-content>, increased odds of osteoporosis and risk of fractures. Proactive monitoring and interventions are required to ameliorate bone loss in AN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12556","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T09:01:00Z","timestamp":1452762060000},"page":"341-351","source":"Crossref","is-referenced-by-count":115,"title":["Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"133","author":[{"given":"M.","family":"Solmi","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Veronese","sequence":"additional","affiliation":[{"name":"Department of Medicine Geriatrics Section University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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