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elevation symptoms (<jats:styled-content style=\"fixed-case\">NOMES<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Among bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) out\u2010patients assessed with Systematic Treatment Enhancement Program for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">STEP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) Affective Disorders Evaluation, we assessed prevalence, demographics, and clinical correlates of mixed vs. pure depression, using less inclusive (\u22653 <jats:styled-content style=\"fixed-case\">NOMES<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DSM<\/jats:styled-content>\u20105), more inclusive (\u22652 <jats:styled-content style=\"fixed-case\">NOMES<\/jats:styled-content>), and most inclusive (\u22651 <jats:styled-content style=\"fixed-case\">NOMES<\/jats:styled-content>) definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 153 depressed <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, compared to less inclusive <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u20105 threshold, our more and most inclusive thresholds, yielded approximately two\u2010 and five\u2010fold higher mixed depression rates (7.2%, 15.0%, and 34.6% respectively), and important statistically significant clinical correlates for mixed compared to pure depression (e.g. more lifetime anxiety disorder comorbidity, more current irritability), which were not significant using the <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u20105 threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further studies assessing strengths and limitations of more inclusive mixed depression definitions are warranted, including assessing the extent to which enhanced statistical power vs. other factors contributes to more vs. less inclusive mixed bipolar depression thresholds having more statistically significant clinical correlates, and whether \u2018overlapping\u2019 mood elevation symptoms should be counted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12563","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:50:13Z","timestamp":1458348613000},"page":"189-198","source":"Crossref","is-referenced-by-count":13,"title":["More inclusive bipolar mixed depression definitions by requiring fewer non\u2010overlapping mood elevation symptoms"],"prefix":"10.1111","volume":"134","author":[{"given":"W.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry Seoul Paik Hospital Inje University School of Medicine Seoul South 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