{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:19Z","timestamp":1790377099620,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to investigate the relationship between structural connectivity (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) and functional connectivity (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) in the cingulum in bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) and its various phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We combined resting\u2010state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> of the cingulum and its portions, the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic (<jats:italic>n<\/jats:italic> = 21), depressed (<jats:italic>n<\/jats:italic> = 20), and euthymic (<jats:italic>n<\/jats:italic> = 20) bipolar patients and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) (<jats:italic>n<\/jats:italic> = 42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First, we found decreased <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Second, we observed decreased <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> of the cingulum bundle, particularly in its anterior part, in manic patients when compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Finally, alterations in the cingulum <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> (but not <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) correlated with clinical severity scores while changes in the cingulum <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> (but not <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) were related with neurocognitive deficits in sustained attention in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrate for the first time a reduction in <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and concomitantly in <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. This supports the central role of cingulum connectivity specifically in mania.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12596","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:32:50Z","timestamp":1465345970000},"page":"339-349","source":"Crossref","is-referenced-by-count":44,"title":["Abnormal functional\u2013structural cingulum connectivity in mania: combined functional magnetic resonance imaging\u2010diffusion tensor imaging investigation in different phases of bipolar disorder"],"prefix":"10.1111","volume":"134","author":[{"given":"M.","family":"Martino","sequence":"first","affiliation":[{"name":"Section of Psychiatry Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Magioncalda","sequence":"additional","affiliation":[{"name":"Section of Psychiatry Department of Neuroscience, 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