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This study aimed to assess sensorimotor gating deficits in patients with euthymic bipolar. Furthermore, we analysed the relationships between <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> and clinical and cognitive measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Prepulse inhibition was measured in 64 patients with euthymic bipolar and in 64 control subjects matched for age, gender, education level and smoking status. Clinical characteristics and level of functioning were assessed in all participants using Hamilton Depression Rating Scale (<jats:styled-content style=\"fixed-case\">HDRS<\/jats:styled-content>), Young Mania Rating Scale (<jats:styled-content style=\"fixed-case\">YMRS<\/jats:styled-content>) and Functioning Assessment Short Test (<jats:styled-content style=\"fixed-case\">FAST<\/jats:styled-content>). Cognition was evaluated using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (<jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content>) and the Stroop test as an additional measure of executive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, patients with bipolar disorder exhibited <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> deficits at 60\u2010 and 120\u2010millisecond prepulse\u2013pulse intervals. Among patients with bipolar disorder, <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> was correlated with the social cognition domain of the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> was not significantly correlated with other clinical, functional and neurocognitive variables in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> deficit is a neurobiological marker in euthymic bipolar disorder, which is associated with social cognition but not with other clinical, functional or cognitive measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12604","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T07:04:49Z","timestamp":1465887889000},"page":"350-359","source":"Crossref","is-referenced-by-count":22,"title":["Prepulse inhibition in euthymic bipolar disorder patients in comparison with control subjects"],"prefix":"10.1111","volume":"134","author":[{"given":"E. 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