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Outcome measures included any mental health event (suicide, hospitalization or emergency visit for mental disorders) and physical health event (death other than suicide, hospitalization or emergency visit for physical disorders). Cox proportional hazard models were used to estimate the hazard ratios of the events associated with the use of the different antipsychotic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 18 869 adult patients living in the province of Quebec (Canada) with <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content> and starting antipsychotic drugs between January 1998 and December 2005. Results show that quetiapine and not using any antipsychotics were associated with an increased risk of mental and physical health events as compared to other drugs. The second finding is the confirmation of better performance of clozapine. The results were robust across sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both findings call for an international public health and drug agencies surveillance of \u2018real\u2010world\u2019 antipsychotic medication to ensure the optimal choices in treatment guidelines for <jats:styled-content style=\"fixed-case\">SZ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12621","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T15:55:32Z","timestamp":1468338932000},"page":"374-384","source":"Crossref","is-referenced-by-count":61,"title":["Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real\u2010world observational study"],"prefix":"10.1111","volume":"134","author":[{"given":"A.","family":"Vanasse","sequence":"first","affiliation":[{"name":"D\u00e9partement de m\u00e9decine de famille et de m\u00e9decine d'urgence Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"},{"name":"PRIMUS Group Centre de recherche du CHUS Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Blais","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Courteau","sequence":"additional","affiliation":[{"name":"PRIMUS Group Centre de recherche du CHUS Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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