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In a secondary analysis, findings from both randomized controlled trials and high\u2010quality observational studies were pooled by means of meta\u2010analytic procedures to explore dopaminergic treatment\u2010related new mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies (1716 patients) were included in our meta\u2010analysis of randomized controlled trials. Treatment with dopaminergic agents for bipolar depression was associated with an increase in both response (1671 individuals, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.25, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05 to 1.50) and remission rates (1671 individuals, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.40, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.14, 1.71). There was no evidence of an increased risk of mood switch associated with this treatment (1646 individuals, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.96, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.49, 1.89). Our secondary analysis (1231 individuals) yielded a cumulative incidence of mood switch of 3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0, 5.0) during a mean follow\u2010up period of 7.5 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preliminary findings suggest that dopaminergic agents may represent a useful alternative for the treatment of bipolar depression, with no evidence for a related increase in the risk of mood destabilization during short\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12712","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T13:12:39Z","timestamp":1488546759000},"page":"527-538","source":"Crossref","is-referenced-by-count":33,"title":["Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-1367","authenticated-orcid":false,"given":"A. 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