{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:23Z","timestamp":1787237843188,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n Objective<\/jats:title>\n \n To explore the prevalence and clinical profile of males and females who develop antidepressant treatment\u2010emergent mania (\n ATEM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n From an original sample of 754 patients with\n BD<\/jats:styled-content>\n , we identified\n ATEM<\/jats:styled-content>\n + cases (\n n<\/jats:italic>\n = 75) and\n ATEM<\/jats:styled-content>\n \u2010 controls (\n n<\/jats:italic>\n = 135) that met stringent criteria. We specifically examined the combinations of clinical factors that best classified males and females as\n ATEM<\/jats:styled-content>\n + cases.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010five individuals were classified as\n ATEM<\/jats:styled-content>\n +; 87% of\n ATEM<\/jats:styled-content>\n events occurred during antidepressant monotherapy. Regression analyses demonstrated that the presence of an alcohol and\/or substance use disorder [Odds Ratio (\n OR<\/jats:styled-content>\n ) 6.37], a history of one or more suicide attempts (\n OR<\/jats:styled-content>\n 4.19) and higher number of depressive episodes per year of illness (\n OR<\/jats:styled-content>\n 1.71) correctly classified 73% of males. In contrast, 84% of females were correctly classified on the basis of a positive history of thyroid disorder (\n OR<\/jats:styled-content>\n 3.23), a positive family history of\n BD<\/jats:styled-content>\n I (\n OR<\/jats:styled-content>\n 2.68) and depressive onset polarity (\n OR<\/jats:styled-content>\n 2.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Using stringent definitions of\n ATEM<\/jats:styled-content>\n status to reduce the probability of inclusion of false\u2010positive cases and false\u2010negative controls, we identified for the first time that the risk profiles for the development of an\n ATEM<\/jats:styled-content>\n differ significantly according to gender.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.12728","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T15:44:35Z","timestamp":1491320675000},"page":"479-488","source":"Crossref","is-referenced-by-count":16,"title":["A re\u2010examination of antidepressant treatment\u2010emergent mania in bipolar disorders: evidence of gender differences"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-8601","authenticated-orcid":false,"given":"J.","family":"Scott","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Newcastle University Newcastle upon Tyne UK"},{"name":"Centre for Affective Disorders IoPPN Kings College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brichant\u2010Petitjean","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Saint\u2010Louis\u2010Lariboisi\u00e8re\u2010Fernand Widal AP\u2010HP Paris France"},{"name":"INSERM Unit\u00e9 UMR\u2010S 1144 Variabilit\u00e9 de R\u00e9ponse aux Psychotropes Universit\u00e9 Paris Descartes\u2010Paris Diderot Paris France"},{"name":"Universit\u00e9 Paris Diderot Paris 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