{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:31:26Z","timestamp":1790375486249,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01GV0606 to LTVE"],"award-info":[{"award-number":["BMBF 01GV0606 to LTVE"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>White matter (WM) alterations have been reported in children and adults with autism spectrum disorder (ASD). In particular, impaired connectivity of limbic structures may be related to social deficits. Heterogeneous findings could be explained in terms of differences in sample characteristics and methodology. In this context, non\u2010syndromic forms might differ substantially in WM structure from secondary ASD forms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In an attempt to recruit a homogeneous study sample, we included adults with high\u2010functioning ASD and an IQ &gt; 100 to decrease the influence of syndromic forms being often associated with cognitive deficits. Diffusion tensor imaging (DTI) was performed in 30 participants with ASD and 30 pairwise\u2010matched controls. Fractional anisotropy (FA) and mean diffusivity (MD) as surrogate imaging markers for WM integrity were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a significant FA decrease in the ASD group in the genu and body of the corpus callosum (CC). Increased MD was detected in the subgenual anterior cingulate cortex (sACC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The finding of decreased WM integrity in the genu of the CC is in line with earlier studies reporting a decreased number of interhemispheric fibers in the frontal lobe of ASD. Alterations in the sACC might be associated with \u2018Theory of mind\u2019 deficits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12731","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:30:03Z","timestamp":1492108203000},"page":"573-583","source":"Crossref","is-referenced-by-count":32,"title":["Altered white matter integrity in adults with autism spectrum disorder and an IQ &gt;100: a diffusion tensor imaging study"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-317X","authenticated-orcid":false,"given":"K.","family":"Nickel","sequence":"first","affiliation":[{"name":"Section for Experimental Neuropsychiatry Department for Psychiatry &amp; Psychotherapy Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tebartz van Elst","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry Department for Psychiatry &amp; Psychotherapy Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Perlov","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry Department for Psychiatry &amp; Psychotherapy Medical Center \u2013 University of Freiburg Freiburg Germany"},{"name":"Luzerner Psychiatrie Hospital St. Urban St. Urban Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Endres","sequence":"additional","affiliation":[{"name":"Section for Experimental Neuropsychiatry Department for Psychiatry &amp; Psychotherapy Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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