{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:54:58Z","timestamp":1760820898293,"version":"3.37.3"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Objective<\/jats:title>The objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC<\/jats:styled-content>) enhances outcomes in patients with early psychosis compared to standard care (SC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>ACCESS III<\/jats:styled-content> is a prospective non\u2010randomized historical control design 1\u2010year study examining the efficacy of EDIC<\/jats:styled-content> (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>120) vs. SC<\/jats:styled-content> (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>105) in patients aged 12\u201329\u00a0years. Primary outcome was the rate of \u22656\u00a0months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP<\/jats:styled-content> and course of psychopathology, functioning, quality of life, and satisfaction with care.<\/jats:p><\/jats:sec>Results<\/jats:title>In observed cases, 48.9% in the EDIC<\/jats:styled-content> and 15.2% in the SC<\/jats:styled-content> group reached the primary endpoint. Remission was predicted by EDIC<\/jats:styled-content> (OR\u00a0=\u00a06.8, CI: 3.15\u201314.53, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001); younger age predicted non\u2010remission (OR<\/jats:styled-content>\u00a0=\u00a01.1, CI<\/jats:styled-content>: 1.01\u20131.19, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.038). Linear regressions indicated a reduction of DUP<\/jats:styled-content> in EDIC<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001), but not in SC<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.41). MMRM<\/jats:styled-content>s showed significantly larger improvements in PANSS<\/jats:styled-content> positive (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and GAF<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01) scores in EDIC<\/jats:styled-content> vs. SC<\/jats:styled-content>, and in EDIC<\/jats:styled-content> over time in CGI<\/jats:styled-content>\u2010Severity (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and numerically in Q\u2010LES<\/jats:styled-content>\u2010Q\u201018 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.052).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>EDIC<\/jats:styled-content> lead to significantly higher proportions of patients achieving combined remission. Moderating variables included a reduction of DUP<\/jats:styled-content> and EDIC<\/jats:styled-content>, offering psychotherapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12762","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T03:52:39Z","timestamp":1496807559000},"page":"188-200","source":"Crossref","is-referenced-by-count":22,"title":["Early detection and integrated care for adolescents and young adults with psychotic disorders: the ACCESS III study"],"prefix":"10.1111","volume":"136","author":[{"given":"M.","family":"Lambert","sequence":"first","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-727X","authenticated-orcid":false,"given":"D.","family":"Sch\u00f6ttle","sequence":"additional","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ruppelt","sequence":"additional","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rohenkohl","sequence":"additional","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sengutta","sequence":"additional","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Luedecke","sequence":"additional","affiliation":[{"name":"Psychosis Centre Department of Psychiatry and Psychotherapy Centre for Psychosocial Medicine University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"},{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics UKE Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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