{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:19:55Z","timestamp":1791357595516,"version":"4.3.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006751","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008976","name":"Sanofi-Aventis Korea Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008976","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n Objective<\/jats:title>\n \n To evaluate aggressiveness during a major depressive episode (\n MDE<\/jats:styled-content>\n ) and its relationship with bipolar disorder (\n BD<\/jats:styled-content>\n ) in a post hoc analysis of the\n BRIDGE<\/jats:styled-content>\n \u2010\n II<\/jats:styled-content>\n \u2010\n MIX<\/jats:styled-content>\n study.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n A total of 2811 individuals were enrolled in this multicenter cross\u2010sectional study.\n MDE<\/jats:styled-content>\n patients with (\n MDE<\/jats:styled-content>\n \u2010A,\n n<\/jats:italic>\n = 399) and without aggressiveness (\n MDE<\/jats:styled-content>\n \u2010N,\n n<\/jats:italic>\n = 2412) were compared through chi\u2010square test or Student's\n t<\/jats:italic>\n \u2010test. A stepwise backward logistic regression model was performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n MDE<\/jats:styled-content>\n \u2010A group was more frequently associated with\n BD<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001), while aggressiveness was negatively correlated with unipolar depression (\n P<\/jats:italic>\n < 0.001). At the logistic regression, aggressiveness was associated with the age at first depressive episode (\n P<\/jats:italic>\n < 0.001); the severity of mania (\n P<\/jats:italic>\n = 0.03); the diagnosis of\n BD<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.001); comorbid borderline personality disorder (\n BPD<\/jats:styled-content>\n ) (\n P<\/jats:italic>\n < 0.001) but not substance abuse (\n P<\/jats:italic>\n = 0.63); no current psychiatric treatment (\n P<\/jats:italic>\n < 0.001); psychotic symptoms (\n P<\/jats:italic>\n = 0.007); the marked social\/occupational impairment (\n P<\/jats:italic>\n = 0.002). The variable most significantly associated with aggressiveness was the presence of\n DSM<\/jats:styled-content>\n \u20105 mixed features (\n P<\/jats:italic>\n < 0.001, OR = 3.815). After the exclusion of\n BPD<\/jats:styled-content>\n , the variable of lifetime suicide attempts became significant (\n P<\/jats:italic>\n = 0.013, OR = 1.405).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Aggressiveness seems to be significantly associated with bipolar spectrum disorders, independently from\n BPD<\/jats:styled-content>\n and substance abuse. Aggressiveness should be considered as a diagnostic criterion for the mixed features specifier and a target of tailored treatment strategy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.12777","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T07:04:46Z","timestamp":1500966286000},"page":"362-372","source":"Crossref","is-referenced-by-count":34,"title":["Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features"],"prefix":"10.1111","volume":"136","author":[{"given":"N.","family":"Verdolini","sequence":"first","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Division of Psychiatry, Clinical Psychology and Rehabilitation Department of Medicine University of Perugia Santa Maria della Misericordia Hospital Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Perugi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinic Medicine Section of Psychiatry University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Samalin","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Department of Psychiatry CHU Clermont\u2010Ferrand University of Auvergne EA 7280 Clermont\u2010Ferrand France"},{"name":"Fondation FondaMental H\u00f4pital Albert Chenevier P\u00f4le de Psychiatrie Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Murru","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Angst","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010M.","family":"Azorin","sequence":"additional","affiliation":[{"name":"AP HM Psychiatric Pole Sainte Marguerite Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Bowden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mosolov","sequence":"additional","affiliation":[{"name":"Department for Therapy of Mental Disorders Moscow Research Institute of Psychiatry Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Young","sequence":"additional","affiliation":[{"name":"Centre for Affective Disorders Department of Psychological Medicine Institute of Psychiatry, Psychology & Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barbuti","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Department of Experimental and Clinic Medicine Section of Psychiatry University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Guiso","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Department of Medical Sciences and Public Health University of Cagliari and Psychiatric Clinic University Hospital Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Popovic","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"},{"name":"Psychiatry B The Chaim Sheba Medical Center Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"E.","family":"Vieta","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pacchiarotti","sequence":"additional","affiliation":[{"name":"Bipolar Disorders Unit Hospital Clinic Institute of Neurosciences University of Barcelona IDIBAPS CIBERSAM Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BRIDGE\u2010II\u2010Mix Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"The psychobiology of aggression","author":"Moyer KE","year":"1976"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1753-2000-3-35"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.11.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12168"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2016.08.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2134"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.6.968"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1521\/suli.34.2.172.32783"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01006.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1614.2000.00802.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2014.06.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01194.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00489.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.27"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.01.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_18_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1980"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.03.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.12.031"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.05.035"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09092"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12457"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12338"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770060086012"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00123-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.87"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0393-4"},{"key":"e_1_2_10_30_1","first-page":"9","article-title":"A study of effects of MultiCollinearity in the multivariable analysis","volume":"4","author":"Yoo W","year":"2014","journal-title":"Int J Appl Sci Technol"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.06.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1001"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02001.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.05.048"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09071011"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-011-0228-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.032"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000869"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12213"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.09.001"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.09.026"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.05.036"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358808"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.00963.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30347-9"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020185"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01528.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00129-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.8.1433"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.02.119"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.021"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415585583"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2007.07.003"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852914000376"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2015.1132007"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116636545"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0338"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.04.002"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070826"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.118"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.12777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.12777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T08:43:57Z","timestamp":1695458637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.12777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/acps.12777"],"URL":"https:\/\/doi.org\/10.1111\/acps.12777","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731320046.793537225","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]}}}