{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:42:47Z","timestamp":1791517367798,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_170249"],"award-info":[{"award-number":["320030_170249"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as\n                      <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>\n                      can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      100 \u03bcg LSD was administrated orally to 20 healthy participants prior to\n                      <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>\n                      assessment. Whole brain thalamic functional connectivity was measured using\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      \u2010to\u2010\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      \u2010to\u2010voxel approaches. Correlation analyses were used to explore relationships between thalamic connectivity to regions involved in auditory and visual hallucinations and subjective ratings on auditory and visual drug effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LSD caused significant alterations in all dimensions of the 5D\u2010\n                      <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                      scale and significantly increased thalamic functional connectivity to various cortical regions. Furthermore,\n                      <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>\n                      \u2010induced functional connectivity measures between the thalamus and the right fusiform gyrus and insula correlated significantly with subjective auditory and visual drug effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Hallucinogenic drug effects might be provoked by facilitations of cortical excitability via thalamocortical interactions. Our findings have implications for the understanding of the mechanism of action of hallucinogenic drugs and provide further insight into the role of the 5\u2010\n                      <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\n                      <jats:sub>2A<\/jats:sub>\n                      \u2010receptor in altered states of consciousness.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.12818","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T04:42:39Z","timestamp":1505968959000},"page":"648-657","source":"Crossref","is-referenced-by-count":143,"title":["Increased thalamic resting\u2010state connectivity as a core driver of LSD\u2010induced hallucinations"],"prefix":"10.1111","volume":"136","author":[{"given":"F.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Psychiatry (UPK) University of Basel Basel 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