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However, we are still lacking studies to adjust for baseline psychotic experiences and other substance use. We examined associations between daily smoking and psychosis risk in a 15\u2010year follow\u2010up while accounting for these covariates in a prospective sample (\n                      <jats:italic>N<\/jats:italic>\n                      = 6081) from the Northern Finland Birth Cohort 1986.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Self\u2010report questionnaires on psychotic experiences (\n                      <jats:styled-content style=\"fixed-case\">PROD<\/jats:styled-content>\n                      \u2010screen), tobacco smoking and other substance use were completed when the cohort members were 15\u201316 years old. Tobacco smoking was categorized into three groups (non\u2010smokers, 1\u20139 cigarettes and \u226510 cigarettes\/day). Psychosis diagnoses were obtained from national registers until the age of 30 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Subjects in heaviest smoking category were at increased risk of subsequent psychosis (unadjusted\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 3.15; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.94\u20135.13). When adjusted for baseline psychotic experiences the association persisted (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 2.87; 1.76\u20134.68) and remained significant even after adjustments for multiple known risk factors such as cannabis use, frequent alcohol use, other illicit substance use, parental substance abuse, and psychosis. Furthermore, number of smoked cigarettes increased psychosis risk in a dose\u2013response manner (adjusted\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      = 1.05; 1.01\u20131.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Heavy tobacco smoking in adolescence was associated with a greater risk for psychosis even after adjustment for confounders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.12863","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T22:52:56Z","timestamp":1518994376000},"page":"5-14","source":"Crossref","is-referenced-by-count":51,"title":["Smokin\u2018 hot: adolescent smoking and the risk of psychosis"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-2122","authenticated-orcid":false,"given":"A.","family":"Mustonen","sequence":"first","affiliation":[{"name":"Center for Life Course Health Research University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ahokas","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"},{"name":"Department of Psychiatry Research Unit of Clinical Neuroscience University of Oulu Oulu Finland"},{"name":"Department of Psychiatry Oulu University Hospital the Northern Ostrobothnia Hospital District Oulu Finland"},{"name":"Department of Psychiatry L\u00e4nsi\u2010Pohja Healthcare District Tornio Finland"},{"name":"Department of Psychiatry the Middle Ostrobothnia Central Hospital Soite Kokkola Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"},{"name":"Department of Psychiatry Oulu University Hospital the Northern Ostrobothnia Hospital District Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Heiskala","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-6068","authenticated-orcid":false,"given":"J. J.","family":"Mcgrath","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute The University of Queensland St Lucia Qld Australia"},{"name":"Queensland Centre for Mental Health Research The Park Centre for Mental Health Wacol Qld Australia"},{"name":"National Centre for Register\u2010Based Research Aarhus University Business and Social Sciences Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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